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Biobank Cohorts

Millions of samples and associated data from various disease and health conditions at BBMRI.at partner biobanks

 

Over 20 million samples from more than 30 years of collection are stored at BBMRI.at partner biobanks. Nearly one million of samples is newly incoming per year.

 

These samples (human, animal) represent all detected diseases at their natural frequency of occurrence and include also healthy samples.

 

Major sample types include formalin fixed paraffin embedded (FFPE), and fresh frozen tissues, fluid samples (serum, plasma, whole blood, urine, stool, cerebrospinal, follicular and seminal fluids, etc.), stained tissue sections, and digital (whole slide) images from H&E or Immunohistochemically stained tissue slides.

 

 

More about the samples and how to get in contact with BBMRI.at partner biobanks

Search the BBMRI Directory >>

or write an email to contact@bbmri.at (Cornelia Stumptner)

 

Some of many special collections we highlighted and describe below

 

Explore the more detailed cohort profiles below.


"COVID-19 Convalescent Cohort":

BBMRI.at Partner's Sample Collection Profile

"COVID-19 Convalescent Cohort"

 

The "COVID-19 Convalescent Cohort" is a sample collection at Biobank Graz (Med Uni Graz) which is based on a prospective sample cohort for current research on SARS-CoV-2.

 

Biobank Graz recruited participants (from Austria) who had recovered from COVID-19 and grouped them into two sub cohorts (see profile table). Volunteers were invited to fill in a questionnaire and donate various types of samples at different time points (see study design and table).

 

This cohort serves for:

  • the development and validation of new antibody tests and neutralization assays
  • the investigation of antibody titres over time
  • a better characterization of the course of COVID-19
  • the identification of diagnostic or prognostic biomarkers

 

Study design:

 

Participants are invited five times, i.e. 1st visit (time point 0), 2nd visit (after 1 month), 3rd visit (after 2 months), 4th visit (after 5 months), 5th visit (after 12 months), where the samples are collected. At the 1st visit, donors also fill in a questionnaire concerning symptoms, comorbidities, pre-history and lifestyle.

 

 

Disease Area

Research Area

  COVID-19 recovered patients, SARS-CoV-2, PCR test, antibody test

Sample Types

  serum, EDTA buffy coat, EDTA plasma, lithium heparin plasma, sodium citrate  

  plasma, saliva and nasopharyngeal swabs (stored at -80 °C)

Cohort Size

  23.739 aliquots from 364 participants as of March 10th  

Donors

  volunteers who recovered from COVID-19

 

  • Sub cohort I: Persons who were officially tested positive for an infection by PCR test with the SARS-CoV-2 virus, showed symptoms of COVID-19 and recovered. (342 participants)

 

  • Sub cohort II: (22 participants)

  1. Persons who lived together or got in contact with a person officially tested positive by PCR test for SARS-CoV-2 and showed symptoms of COVID-19 disease within 14 days, but were not tested themselves, and recovered.

  2. Persons who showed leading COVID-19 symptoms (fever, dry cough, loss of smell or taste, diarrhoea, fatigue) since December 2019, but were not tested themselves, independent of whether they had contact to a person positive tested for SARS-CoV-2, and recovered.

Associated Data

 

  Data concerning symptoms, comorbidities, prehistory and lifestyle

  are collected via questionnaire

 

PCR tests and  antibody tests are performed

Informed Consent

  Broad Biobank IC (view template de>>; view template en>>), sStudy specific IC

Access

  As of now

Quality Standards

  • Quality management: ISO 9001:2015 (SOPs)

  • CEN/TS 16945:2016 (metabolomics in urine, venous blood serum and plasma)

Contact

 

View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory >>   

View this cohort at Biobank Graz website >>   


Feline lymphoma cohort

BBMRI.at Partner's Sample Collection Profile

"Feline lymphoma cohort":

an outstanding sample collection at VetBiobank Vienna (University of Veterinary Medicine, Vienna)

 

Lymphoma is the most common tumor in cats. This neoplasia can develop in every tissue; however, the gastrointestinal tract is in contrast to dogs and people the most frequent localization in the feline species.

 

The prognosis for cats suffering from intermediate or high-grade lymphoma is still poor and research in this important veterinary area continues to be under-resourced.

 

The clinical cohort comprises neutered and unneutered male and female patients between 7 months and 15 years. Biospecimens are collected according SOPs. Tissue samples are collected in line with the ISO standards 20166 and 20184 and are therefore suitable for molecular investigations.

 

Profile of the feline lymphoma cohort:

Disease Area/

Research Area

Lymphoma in cats

Sample Types

Fixed and native samples from tumor and healthy reference tissues (FFPE, glutaraldehyde for electron microscopy, OCT, RNAlater, pure), serum, plasma, urine, feces;

Cohort Size

  • Complete set of samples and data with follow up examination for 36 patients available;
  • Collection start February 2016 - collection ongoing

Donors

  • untreated, treated
  • age
  • gender

Associated Data

Clinical data (anamnesis, treatment: medication, surgical intervention, laboratory results, imaging data..), sample management data, images from HE-stains;

Informed Consent

Approved by the patient owner

Access to

  • Internal academic research,
  • external academic research,
  • industrial research - cooperation preferred

Quality Standards

 Tissue samples were collected according to the sample pre-analytics standards:  CEN/TS 16826 1-2, CEN/TS 16827  1-3;

Contact

Sample Coordinator: VetBiobank, Ingrid Walter
Email: Ingrid.Walter@vetmeduni.ac.at

 

Principle investigator: Birgitt Wolfesberger

Email: Birgitt.Wolfesberger@vetmeduni.ac.at

 

View cohorts from VetBioBank and other BBMRI.at partner biobanks in the BBMRI-ERIC Directory >>

More about VetBioBank>>

 

 


"LEAD Cohort"

Sample Collection Profile at BBMRI.at Partner

"LEAD Cohort (Austrian LEAD Study)" at BBMRI.at partner MedUni Wien Biobank

 

The Biobank of the Medical University of Vienna harbours the sample cohort of the "Austrian LEAD-Study" collected at the Ludwig Bolzmann Institute (https://copd.lbg.ac.at/en/research-program/austrian-lead-study). It is a population based cohort and one of the largest long-term studies in Austria on the topic of lung health.

 

The LEAD study is a longitudinal, observational, epidemiological cohort study aiming to investigate respiratory health through life. The survey includes a representative sample of the Austrian general population between 6 and 80 years of age and focuses on three areas:

  1. Normal and pathologic lung growth and development (natural history of lung function).

  2. Genetic, environmental and socioeconomic risk factors for abnormal lung function

  3. Extrapulmonary manifestations of abnormal lung function and related comorbidities (cardiovascular disease, metabolic disorders, depression and anxiety).

 

Current status and examination programme of the Austria Lead Study at the Ludwig Bolzmann Institute >>

Contact: Dr. Marie Breyer

      

 

More about MedUni Wien Biobank >>


"INTERFAST cohort"

BBMRI.at Sample Collection Profile

"INTERFAST cohort": an outstanding sample collection at Biobank Graz (Med Uni Graz)

 

"INTERFAST" stands for Intermittent Fasting (i.e. a dietary regimen of alternating fasting and "feeding" cycles, e.g. practised by alternate day fasting). The INTERFAST collection represents cohort of blood and urine samples from healthy donors who have undergone different types of intermittent fasting and is collected in the context of the INTERFAST project (www.interfast.at).

 

The cohort supports studies that aim to investigate the effects of repeating fasting periods on human physiology, aging process and molecular cellular processes in humans.

This includes both studying

  • long term effects of fasting (as donors are included in the cohort, who already practice alternate day fasting (ADF) for a defined time period) as well as

  • short term effects of this nutritional intervention (i.e. intermittent fasting).

 

The INTERFAST cohort comprises serum, plasma and urine samples.

 

Profile of the INTERFAST Cohort:

Disease Area

Research Area

Intermittent fasting, alternate day fasting (ADF), effects on autophagy, human physiology, aging process and molecular-cellular processes

Sample Types

Serum, plasma and urine samples stored at -80°C

Cohort Size

 90 donors:

  • 30 subjects cohort - 2 study visits

  • 60 subjects RCT - 4 study visits

Donors

Cohort (Alternate day fasting for at least 6 months before the start of the trial – 30 subjects) as well as randomized control-trial (60 subjects – randomized to either intervention group (alternate day fasting) or control group with no intervention 1:1).

 

Adults 35 - 65 years; ratio female:male = 57:43

Further inclusion criteria:

  • Body mass index in the range of 22.0 – 30.0 kg/m2
  • Fasting blood glucose <110mg/dL (without medication)
  • LDL-cholesterol <180 mg/dL (without medication)
  • Blood pressure <140/90 mmHg (without medication)
  • Stable weight (change <± 10%) for 3 months immediately

Exclusion criteria: see INTERFAST cohort details >>

Associated Data

  • Demographics
  • Medical history
  • Concomitant medication
  • Vital signs
  • Physical examination
  • Blood sampling with oral glucose tolerance test (oGTT)
  • Electrocardiogram (ECG)

 

Informed Consent

 Broad Biobank IC (view template de>>; view template en>>), specific study IC

Access

   Cooperation  preferred

Quality Standards

Quality management: ISO 9001:2015 (SOPs)

Contact

 

Publication: "Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial" (Advances in Therapy, August 2018, Volume 35, Issue 8) … download

 

Media article:  ORF REPORT: "Life-threatening sick: new rapid test" … more

 

View INTERFAST cohort profile form from Biobank Graz >>


View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory >>

 

 



Paracelsus 10.000 Cohort

BBMRI.at Sample Collection Profile

"Paracelsus 10 000 Cohort" - at population-based collection at BBMRI.at partner PMU / SALK

 

This  population-based collection of the of samples and data is soon going to reached the mark of 10 000 donors. It comprises samples and data from 5 000 male and 5 000 female probands from Salzburg (Austria).

 

Purpose of this cohort is to serve the following study aims:

  • Collection of valid epidemiological data on the state of health of the Salzburg population

  • Clarification of the interaction of genetic disposition and lifestyle factors in the development of degenerative diseases

  • Development of well-directed prevention processes for the population of Salzburg

  • Strengthening of the research location Salzburg and Austria

 

CONTACT:

 

 

COHORT SIZE & DONORS

 

Representative sample of 10 000 participants (5.000 male, 5.000 female)-by 03/2020- from the city of Salzburg and surrounding townships:

  • 40-49 years: 2700 participants

  • 50-59 years: 4300 participants

  • 60-69 years: 3000 participants

 

SAMPLE TYPES

  • Plasma (EDTA, citrate and

  • heparin)                                             

  • Serum

  • EDTA blood for DNA isolation

  • Buffy Coat

  • Urine

  • Stool samples

 

ASSOCIATED DATA

 

1. Basic investigations of all participants:

  • Questionnaires on diet, exercise, socio-economic anamnesis, depression, cognitive performance, quality of life, stress and environmental factors

  • Anthropometry: height, weight, abdominal girth

  • Resting blood pressure, heart rate, resting 12-channel ECG

  • Laboratory parameters:

  • Lipid profile, Apo-B, Apo-AI, Lp(a), FBS, HbA1c, E-lyte, CR, Urea, LFT, Fe-Status, hsCRP, fibrinogen, BC, TSH, PSA (men), Fasting-Insulin

  • Urine: chemistry, albumin/creatinine ratio

  • Ultrasound of the carotides

 

2. Additional investigations for the intensively phenotyped subgroup (50 to 59 years):

  • Laboratory parameters: fasting proinsulin, free fatty acids, adiponectin, vitamin D

  • Determination of insulin sensitivity and beta cell function by frequently sampled OGTT (with simultaneous determination of insulin, C-peptide and blood glucose at the time points 0 min., 30 min., 60 min., 90 min. and 120 min.)

  • Pulmonary function test

  • Pulse wave analysis

  • Multi-frequency body composition B.I.A.

  • Measurement of intima-media thickness and plaque score of carotid arteries

  • Measurement of the coronary artery calcium score

  • 24h blood pressure measurement

  • 7-day nutrition protocol

  • 7-day movement monitoring using movement sensors

  • Ankle-brachial index

  • Hand grip

  • 6 meter walking test


3. Additional investigations for two participants per day (50 to 59 years):

  • Coronary ca-score

  • Body fat distribution and bone density (measured with DEXA-scan)

  • Ergospirometry

  • Ultrasound of the liver

 

View details at SALK website >>

View details (pdf) >>


"PERFORM cohort"

BBMRI.at Partner's Sample Collection Profile

"PERFORM cohort": an outstanding sample collection at Biobank Graz (Med Uni Graz)

 

"PERFORM" stands for Personalised Risk assessment in Febrile illness to Optimise Real-life Management across the European Union. It represents a pediatric cohort of samples from children and is collected in the context of the PERFORM EU Horizon 2020 project.

 

The collection aims to improve the diagnostics in febrile children and adolescents and to develop a comprehensive management plan for febrile patients in Europe. It helps to improve the diagnostics in febrile children and adolescents.

 

The "PERFORM cohort" comprises PAXgene stabilized and EDTA blood samples (whole blood, plasma, pellet), cerebrospinal fluid, throat swab, urine and stool. It includes children below the age of 18 (both genders) with i) fever >38ºC, or a history of fever (within 3 days), or ii) suspected of infection.

 

Profile of the PERFORM Cohort:

Disease Area

Research Area

Febrile illness

Sample Types

ETDA blood (plasma, pellet and whole blood), blood in PAXgene tubes, cerebrospinal fluid, throat swab, urine, and stool stored at -80°C

Cohort Size

 Samples from 500 patients

Donors

Children <18 years

  • with fever >38ºC, or a history of fever (within 3 days), in whom the attending clinician determines the need for blood sampling or whom parents give consent for bloods taken for research purposes.
  • suspected of infection (included: full spectrum of disease severity, and with co-morbidities)

Associated Data

   --

Informed Consent

   Specific study IC 

Access

   Cooperation only

Quality Standards

 

  • Quality management: ISO 9001:2015 (SOPs)

Contact

 

More details about the PERFORM Cohort >>

 

View PERFORM cohort profile from Biobank Graz >>


View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory >>

 

 

(C) Medical University of Graz


Osteoporosis cohort - 2nd portrait of a BBMRI.at sample collection

BBMRI.at Partner's Sample Collection Profile

"PoCOsteo" osteoporosis cohort

an outstanding osteoporosis sample collection at Biobank Graz, Med Uni Graz

 

"PoCOsteo" stands for Point-of-care in-office device for identifying individuals at high risk of Osteoporosis and osteoporotic fracture.

It is being collected (starting May 2018) in the context of the HORIZON 2020 project PoCOsteo (Proposal number 767325) which aims at developing point-of-care in-vitro devices to measure and/or quantify proteomic and genomic factors in human whole blood.

 

The clinical cohort includes male and female patients fifty years and above and ranges from healthy (per definition) to those who experienced multiple fragility fractures due to secondary osteoporosis.

It comprises untreated patients as well as those treated for osteoporosis, with or without concomitant diseases such as hypertension, diabetes etc.

 

The samples meet the requirements of the sample quality standards "CEN/TC 140 Molecular in vitro diagnostic examinations - Specifications for preexamination processes (CEN/TS) for metabolomics in urine, venous blood serum and plasma" (CEN/TS 16945:2016) that were published by the European Committee for Standardization (CEN). More about sample types and quality in our BBMRI.at Catalogue >>

                       

(C) BBMRI.at (Medical University of Graz)

 

 

Profile of the PoCOsteo Cohort:

Disease Area

Research Area

Endocrinology, osteoporosis, osteoporotic fractures

Biomarker development & detection

Sample Types

  Serum, EDTA-plasma and buffy coat (stored at -80°C)

Cohort Size

  • 1,000 probands

  • Collection start in May 2018 - collection ongoing

Donors

  • Healthy and diseased, treated and untreated for osteoporosis with or without concomitant diseases (e.g. hypertension, diabetes, …)

  • Age: adults > 50 years;

  • Gender: female and male

Associated Data

From the following time-points: study inclusion, after 12 and possibly 24 months: bone mineral density (BMD) of the hip and the lumbar spine as well as vertebral fracture assessment (VFA) by Dual X-ray absorptiometry (DXA), grip strength (hydraulic hand dynamometer), and a routine blood test including renal and hepatic parameters together with a lipid profile

Informed Consent

   Broad Biobank IC (view template >>) & specific study IC

Access

   Cooperation preferred

Quality Standards

Contact

 

 

More details about the PoCOsteo Cohort >>

 

View PoCOsteo cohort profile form of Biobank Graz >>

 

 


“BioPersMed cohort” - 1st portrait of a BBMRI.at sample collection

BBMRI.at Partner's Sample Collection Profile

"BioPersMed cohort":

an outstanding interdisciplinary sample collection at Biobank Graz

 

"BioPersMed" stands for "Biomarkers for Personalised Medicine in Common Metabolic Disorders.

 

This prospectively collected cohort comprises a huge number of samples and data being collected and used since 2010 (still ongoing). Aim is to detect and define specific characteristics and personalized biomarkers of patients at risk for cardiovascular and metabolic diseases and to follow them for future developments.

 

The "BioPersMed Cohort" includes the research areas endocrinology & metabolism and cardiology. Diabetes, fatty liver disease, osteoporosis or cardiovascular diseases are only some of the topics in the focus of this cohort.

 

The samples meet the requirements of the sample quality standards "CEN/TC 140 Molecular in vitro diagnostic examinations - Specifications for preexamination processes (CEN/TS) for metabolomics in urine, venous blood serum and plasma" (CEN/TS 16945:2016) that were published by the European Committee for Standardization (CEN). More about sample types and quality in the BBMRI Directory >>

                         

 

 

(C) Bernhard Bergmann

(provided by Medical University of Graz)

 

 

 

 

Profile of the BioPersMed Cohort:

Disease Area

Research Area

   Diabetes, fatty liver disease, osteoporosis, cardiovascular diseases.

   Biomarker, endocrinology,  metabolism, cardiology;

Sample Types

   Plasma (EDTA, Lithium Heparin, Sodium Citrate), serum, buffy coat

   urine, 24h urine of healthy and diseased patients

Cohort Size

  • 1,024 probands (in 4 follow-up visits): healthy and diseased
  • >220,000 aliquots (as per March 2018)
  • collection ongoing

Donors

  • Healthy and diseased,
  • Age: adults 35+ years;
  • Gender: 50/50 female/male

Associated Data

   Clinical records/diagnosis, smoking and lifestyle anamnesis,

   follow-up laboratory results, follow-up clinical data

   view detailed  phenotyping description (abstract) >>

Informed Consent

   Broad Biobank IC (view template >>) & specific study IC

Access

   Cooperation only

Quality Standards

Contact

 

More details about the BioPersMed Cohort >>

 

View BioPersMed cohort profile form of Biobank Graz>>

 

 


Asset Publisher Asset Publisher

Feline lymphoma cohort

a sample cohort by VetBiobank Vienna


Another Austria biobank sample cohort meets CEN/TS requirements:

PoCOsteo cohort at Biobank Graz – July 2020


"LEAD Cohort"

from Ludwig Bolzmann Institute at MedUniWien Biobank (June 2020)


Paracelsus 10.000 Cohort

a population based sample collection at BBMRI.at partner in Salzburg


Osteoporosis cohort - 2nd portrait of a BBMRI.at sample collection

This collection is located at Biobank Graz (July 2018)


"PERFORM cohort"

a sample cohort by Biobank Graz


ORF Report about Med Uni Graz Research & Biobank Graz samples

a cohort in Biobank Graz - Feb 2020


“BioPersMed cohort” - 1st portrait of a BBMRI.at sample collection

This collection is located at Biobank Graz (May, 2018)


"INTERFAST cohort"

a sample cohort by Biobank Graz


"COVID-19 Convalescent Cohort":

a cohort in Biobank Graz - Apr 2021


FFPE Tissue Blocks & Slides Biobank Collection

a cohort at Biobank Graz - August 2021