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Sars-CoV-2 test specificity & sensitivity
Publication by BBMRI.at partner Med Uni Wien / MedUni Wien Biobank
Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology
Sep 2022
| With support from BBMRI.at partner Med Uni Wien Biobank researchers from Vienna used samples from Austrian cohorts to investigate sensitivity and specificity of test systems. In their publication, they propose a novel testing strategy to increase the specificity of tests without compromising their sensitivity.
Serological tests are often poor with respect to sensitivity and specificity and leave room for false-positive and false-negative results.
On the example of COVID-19, the researchers from Med Uni Wien & Biobank tested five different serologic antibody SARS-CoV-2 tests. The scientists now propose a novel test algorithm - termed ‘sensitivity-improved two-test, SIT²'. For developing and testing the algorithm samples from an Austrian cohort stored at and managed by Med Uni Wien Biobank were used.
Read original article:
Perkmann T, Koller T, Perkmann-Nagele N, […] Helmuth Haslacher. Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology. J of Clin Pathol, Published Online First: 30 August 2022. doi: 10.1136/jcp-2022-208171
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