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Collaboration of BBMRI.at biobanks and researchers on Sars-CoV-2
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Collaboration of BBMRI.at biobanks and researchers leads to new findings concerning the relevance of sample pre-analytics in SARS-CoV-2 samples
In a collaboration project between MedUni Wien Biobank, Biobank Graz and researchers from several clinical departments of the Medical Universities of Graz and Vienna, short-term and long-term storage stabilities of SARS-CoV-2 antibodies were evaluated using samples from the Biobank's SARS-CoV-2 cohorts.
Moreover, the authors highlighted the problems with evaluating long-term storage effects, as the evaluation tool (the analytical test itself) also changes over time, which introduces additional analytical imprecision and leads to overestimation of the pre-analytical variability.
The paper was published in the top laboratory journal Clinical Chemistry and Laboratory Medicine (impact factor: 8.49):
Niedrist T, Kriegl L, Zurl CJ, Schmidt F, Perkmann-Nagele N, Mucher P, Repl M, Flieder I, Radakovics A, Sieghart D, Radner H, Aletaha D, Binder CJ, Gülly C, Krause R, Herrmann M, Wagner OF, Perkmann T, Haslacher H.
Preanalytical stability of SARS-CoV-2 anti-nucleocapsid antibodies.
Clin Chem Lab Med. 2022 Nov 4.
doi: 10.1515/cclm-2022-0875. Epub ahead of print. PMID: 36323338.