Lower Levels of ABO Anti-A and Anti-B of IgM, IgG and IgA Isotypes in the Serum but Not the Saliva of COVID-19 Convalescents
With support from Biobank Graz, researchers at Med Uni Graz have established a COVID-19 Convalescent Cohort. Recently a new scientific paper on differences in antibody levels in saliva and serum was published presenting findings from this cohort.
Individuals with ABO type O, naturally possessing anti-A and anti-B antibodies in their serum, are underrepresented among patients infected with SARS-CoV-2 compared with healthy controls. The ABO antibodies might play a role in the viral transmission.
Whereas ABO antibodies in the saliva may not contribute to the pathogenesis of COVID-19, individual pre-existing high serum concentrations of anti-A/anti-B may have a protective effect against SARS-CoV-2 infection.
Matzhold, E.M.; Körmöczi, G.F.; Banfi, C.; Schönbacher, M.; Drexler-Helmberg, C.; Steinmetz, I.; Berghold, A.; Schlenke, P.; Wagner, G.E.; Stoisser, A.; Kleinhappl, B.; Mayr, W.R.; Wagner, T. Lower Levels of ABO Anti-A and Anti-B of IgM, IgG and IgA Isotypes in the Serum but Not the Saliva of COVID-19 Convalescents. J. Clin. Med. 2022, 11, 4513.
