Born in Vienna (BiV) – Pilot Birth Cohort Austria
An exellent cohort from BBMRI.at partner Medical University of Vienna at MedUni Wien Biobank
Scientist Claudia Gundacker and her team at MedUni Vienna build this cohort to investigate early life exposure. This includes chemical exposures, lifestyle, socioeconomic conditions, infections, and even heat stress. The BBMRI.at partner MedUni Wien Biobank takes over secure sample storage.
Profile of the cohort:
Research Area
Early Life Exposome
Cohort Type
Birth Cohort, disease-based
Cohort Size
150-200 participants
Biological Sample Types (with storage condition)
• EDTA whole blood, serum (-80°C) (maternal blood, cord blood)
• Placenta, frozen tissue (~-150°C in liquid nitrogen vapour phase)
• Placenta, whole soft tissue (RNAlater)
• Placenta, whole soft tissue (-80°C)
• Selected samples:
– Primary cells (-200°C, liquid nitrogen)
– Primary cell lysates (cDNA and/or protein, -80°C)
– FFPE block (RT), cryo blocks (-80°C, Tissue Tek)
• Placenta, frozen tissue (~-150°C in liquid nitrogen vapour phase)
• Placenta, whole soft tissue (RNAlater)
• Placenta, whole soft tissue (-80°C)
• Selected samples:
– Primary cells (-200°C, liquid nitrogen)
– Primary cell lysates (cDNA and/or protein, -80°C)
– FFPE block (RT), cryo blocks (-80°C, Tissue Tek)
Associated Data
Medical record, questionnaire including food frequency questionnaire
Donors Details
• Maternal age
• Offspring sex
• Maternal education and profession
• Maternal health/disease status
• Maternal area of residence, urban/rural, distance to industry etc.
• Diet (FFQ)
• Use of dietary supplements, cohort-specific medication etc.
• Lifestyle habits such as smoking, diet, exposure sources, etc.
• Offspring sex
• Maternal education and profession
• Maternal health/disease status
• Maternal area of residence, urban/rural, distance to industry etc.
• Diet (FFQ)
• Use of dietary supplements, cohort-specific medication etc.
• Lifestyle habits such as smoking, diet, exposure sources, etc.
Collection Period
2025-2029
Informed Consent
Broad consent and study specific consent
Access
Yes – collaboration only
Quality Standards
The biological samples are stored at MedUni Wien Biobank which is included in quality management systems according to ISO 9001:2015.
Contact
Principle Investiagator:
Assoc. Prof. PD. Mag. Dr. Claudia Gundacker,
claudia.gundacker@meduniwien.ac.at
Assoc. Prof. PD. Mag. Dr. Claudia Gundacker,
claudia.gundacker@meduniwien.ac.at
Research projects
• PARC – European Partnership for the Assessment of Risks from Chemicals
• 2022-2027 (EU Horizon Europe)
• 2022-2027 (EU Horizon Europe)
- Kaiser AM, Forsthuber M, Widhalm R, Granitzer S, Weiss S, Zeisler H, Foessleitner P, Salzer H, Grasl-Kraupp B, Moshammer H, Hartmann C, Uhl M, Gundacker C. Prenatal exposure to per- and polyfluoroalkyl substances and pregnancy outcome in Austria. Ecotoxicol Environ Saf. (Jul 2023); https://doi: 10.1016/j.ecoenv.2023.115006, PMID: 37182303
