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"COVID-19 Convalescent Cohort":

BBMRI.at Partner's Sample Collection Profile

"COVID-19 Convalescent Cohort"

 

The "COVID-19 Convalescent Cohort" is a sample collection at Biobank Graz (Med Uni Graz) which is based on a prospective sample cohort for current research on SARS-CoV-2.

 

Biobank Graz recruited participants (from Austria) who had recovered from COVID-19 and grouped them into two sub cohorts (see profile table). Volunteers were invited to fill in a questionnaire and donate various types of samples at different time points (see study design and table).

 

This cohort serves for:

  • the development and validation of new antibody tests and neutralization assays
  • the investigation of antibody titres over time
  • a better characterization of the course of COVID-19
  • the identification of diagnostic or prognostic biomarkers

 

Study design:

 

Participants are invited five times, i.e. 1st visit (time point 0), 2nd visit (after 1 month), 3rd visit (after 2 months), 4th visit (after 5 months), 5th visit (after 12 months), where the samples are collected. At the 1st visit, donors also fill in a questionnaire concerning symptoms, comorbidities, pre-history and lifestyle.

 

 

Disease Area

Research Area

  COVID-19 recovered patients, SARS-CoV-2, PCR test, antibody test

Sample Types

  serum, EDTA buffy coat, EDTA plasma, lithium heparin plasma, sodium citrate  

  plasma, saliva and nasopharyngeal swabs (stored at -80 °C)

Cohort Size

  23.739 aliquots from 364 participants as of March 10th  

Donors

  volunteers who recovered from COVID-19

 

  • Sub cohort I: Persons who were officially tested positive for an infection by PCR test with the SARS-CoV-2 virus, showed symptoms of COVID-19 and recovered. (342 participants)

 

  • Sub cohort II: (22 participants)

  1. Persons who lived together or got in contact with a person officially tested positive by PCR test for SARS-CoV-2 and showed symptoms of COVID-19 disease within 14 days, but were not tested themselves, and recovered.

  2. Persons who showed leading COVID-19 symptoms (fever, dry cough, loss of smell or taste, diarrhoea, fatigue) since December 2019, but were not tested themselves, independent of whether they had contact to a person positive tested for SARS-CoV-2, and recovered.

Associated Data

 

  Data concerning symptoms, comorbidities, prehistory and lifestyle

  are collected via questionnaire

 

PCR tests and  antibody tests are performed

Informed Consent

  Broad Biobank IC (view template de>>; view template en>>), sStudy specific IC

Access

  As of now

Quality Standards

  • Quality management: ISO 9001:2015 (SOPs)

  • CEN/TS 16945:2016 (metabolomics in urine, venous blood serum and plasma)

Contact

 

 

 

Publications

 

 

 

 

Kral S, Banfi C, Niedrist T, Sareban N, Guelly C, Kriegl L, Schiffmann S, Zurl C, Herrmann M, Steinmetz I, Schlenke P, Berghold A, Krause R. Long-lasting immune response to a mild course of PCR-confirmed SARS-CoV-2 infection: A cohort study. J Infect. 2021 Nov;83(5):607-635. doi:

 

Niedrist T, Drexler C, Torreiter PP, Matejka J, Strahlhofer-Augsten M, Kral S, Riegler S, Gülly C, Zurl C, Kriegl L, Krause R, Berghold A, Steinmetz I, Schlenke P, Herrmann M. Longitudinal comparison of automated SARS-CoV-2 serology assays in assessing virus neutralization capacity in COVID-19 convalescent sera. Arch Pathol Lab Med. 2022 Jan 27. doi: 10.5858/arpa.2021-0604-SA. Epub ahead of print. PMID: 35085385

 

 

View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory >>   

 

View this cohort at Biobank Graz website >>