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Osteoporosis cohort - 2nd portrait of a BBMRI.at sample collection

BBMRI.at Sample Collection Profile

 

"PoCOsteo cohort": an outstanding osteoporosis sample collection at Biobank Graz, Med Uni Graz

 

 

"PoCOsteo" stands for Point-of-care in-office device for identifying individuals at high risk of Osteoporosis and osteoporotic fracture.

It is being collected (starting May 2018) in the context of the HORIZON 2020 project PoCOsteo (Proposal number 767325) which aims at developing point-of-care in-vitro devices to measure and/or quantify proteomic and genomic factors in human whole blood.

 

The clinical cohort includes male and female patients fifty years and above and ranges from healthy (per definition) to those who experienced multiple fragility fractures due to secondary osteoporosis.

It comprises untreated patients as well as those treated for osteoporosis, with or without concomitant diseases such as hypertension, diabetes etc.

 

The samples meet the requirements of the sample quality standards "CEN/TC 140 Molecular in vitro diagnostic examinations - Specifications for preexamination processes (CEN/TS) for metabolomics in urine, venous blood serum and plasma" (CEN/TS 16945:2016) that were published by the European Committee for Standardization (CEN). More about sample types and quality in our BBMRI.at Catalogue >>

                       

(C) BBMRI.at (Medical University of Graz)

 

 

Profile of the PoCOsteo Cohort:

Disease Area

Research Area

Endocrinology, osteoporosis, osteoporotic fractures

Biomarker development & detection

Sample Types

  Serum, EDTA-plasma and buffy coat (stored at -80°C)

Cohort Size

  • 1,000 probands

  • Collection start in May 2018 - collection ongoing

Donors

  • Healthy and diseased, treated and untreated for osteoporosis with or without concomitant diseases (e.g. hypertension, diabetes, …)

  • Age: adults > 50 years;

  • Gender: female and male

Associated Data

From the following time-points: study inclusion, after 12 and possibly 24 months: bone mineral density (BMD) of the hip and the lumbar spine as well as vertebral fracture assessment (VFA) by Dual X-ray absorptiometry (DXA), grip strength (hydraulic hand dynamometer), and a routine blood test including renal and hepatic parameters together with a lipid profile

Informed Consent

   Broad Biobank IC (view template >>) & specific study IC

Access

   Cooperation preferred

Quality Standards

Contact

 

 

More details about the PoCOsteo Cohort >>