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"COVID-19 Convalescent Cohort":

BBMRI.at Partner's Sample Collection Profile

"COVID-19 Convalescent Cohort"

 

The "COVID-19 Convalescent Cohort" is a sample collection at Biobank Graz (Med Uni Graz) which is based on a prospective sample cohort for current research on SARS-CoV-2.

 

Biobank Graz recruited participants (from Austria) who had recovered from COVID-19 and grouped them into two sub cohorts (see profile table). Volunteers were invited to fill in a questionnaire and donate various types of samples at different time points (see study design and table).

 

This cohort serves for:

  • the development and validation of new antibody tests and neutralization assays
  • the investigation of antibody titres over time
  • a better characterization of the course of COVID-19
  • the identification of diagnostic or prognostic biomarkers

 

Study design:

 

Participants are invited five times, i.e. 1st visit (time point 0), 2nd visit (after 1 month), 3rd visit (after 2 months), 4th visit (after 5 months), 5th visit (after 12 months), where the samples are collected. At the 1st visit, donors also fill in a questionnaire concerning symptoms, comorbidities, pre-history and lifestyle.

 

 

Disease Area

Research Area

  COVID-19 recovered patients, SARS-CoV-2, PCR test, antibody test

Sample Types

  serum, EDTA buffy coat, EDTA plasma, lithium heparin plasma, sodium citrate  

  plasma, saliva and nasopharyngeal swabs (stored at -80 °C)

Cohort Size

  23.739 aliquots from 364 participants as of March 10th  

Donors

  volunteers who recovered from COVID-19

 

  • Sub cohort I: Persons who were officially tested positive for an infection by PCR test with the SARS-CoV-2 virus, showed symptoms of COVID-19 and recovered. (342 participants)

 

  • Sub cohort II: (22 participants)

  1. Persons who lived together or got in contact with a person officially tested positive by PCR test for SARS-CoV-2 and showed symptoms of COVID-19 disease within 14 days, but were not tested themselves, and recovered.

  2. Persons who showed leading COVID-19 symptoms (fever, dry cough, loss of smell or taste, diarrhoea, fatigue) since December 2019, but were not tested themselves, independent of whether they had contact to a person positive tested for SARS-CoV-2, and recovered.

Associated Data

 

  Data concerning symptoms, comorbidities, prehistory and lifestyle

  are collected via questionnaire

 

PCR tests and  antibody tests are performed

Informed Consent

  Broad Biobank IC (view template de>>; view template en>>), sStudy specific IC

Access

  As of now

Quality Standards

  • Quality management: ISO 9001:2015 (SOPs)

  • CEN/TS 16945:2016 (metabolomics in urine, venous blood serum and plasma)

Contact

 

View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory >>   

View this cohort at Biobank Graz website >>