{"id":679,"date":"2022-10-11T16:52:18","date_gmt":"2022-10-11T14:52:18","guid":{"rendered":"https:\/\/bbmri.at\/?page_id=679"},"modified":"2025-10-22T08:39:33","modified_gmt":"2025-10-22T06:39:33","slug":"biobank-cohorts","status":"publish","type":"page","link":"https:\/\/bbmri.at\/de\/fuer-forscherinnen\/biobank-cohorts\/","title":{"rendered":"Biobank Kohorten"},"content":{"rendered":"    <div id=\"main_textblock_d15601e16629803e5648007aa5124458\" class=\"content-row content-row-main_text\">\n        <div class=\"contentPart-main contentPart-main-main_text trans \">\n            <div class=\"contentPart_inner\">\n                \n                                    <h1 class=\"heading_main_txt HL_main\">\n                        Biobank Kohorten                    <\/h1>\n                \n                                    <h3 class=\"subheading_main_txt HL_sub\">\n                        BBMRI.at Partnerbiobanken beherbergen Millionen von Proben und zugeh\u00f6rigen Daten zu verschiedenen Krankheiten und Gesundheitszust\u00e4nden.                    <\/h3>\n                \n                                    <div class=\"text_main_text text1624 main_text_margin\">\n                        <p>Mehr als 20 Millionen Proben von \u00fcber 30 Jahren Sammlung werden bei den BBMRI.at Partnerbiobanken gelagert. J\u00e4hrlich kommen fast eine Million neue Proben dazu.<\/p>\n<p>Diese Proben (Mensch, Tier) repr\u00e4sentieren alle bekannten Krankheiten in ihrer nat\u00fcrlichen H\u00e4ufigkeit und umfassen auch gesunde Proben.<\/p>\n<p>Zu den wichtigsten Probentypen geh\u00f6ren in Formalin fixiertes, in Paraffin eingebettetes (FFPE) und frisch eingefrorenes Gewebe, Fl\u00fcssigproben (Serum, Plasma, Vollblut, Urin, Stuhl, Liquor, Follikel- und Samenfl\u00fcssigkeit usw.), gef\u00e4rbte Gewebeschnitte und digitale (ganzer Schnitt) Bilder von H&amp;E- oder immunhistochemisch gef\u00e4rbten Gewebeschnitten.<\/p>\n                    <\/div>\n                \n                            <\/div>\n\n\n\n            <div class=\"contentPart-sidebarDummy\"><\/div>\n        <\/div>\n\n    <\/div>\n\n\n    <div id=\"plain_textfieldblock_2a89e495c967268738652c268e4b6ee6\" class=\"content-row content-row-plain_textfield\">\r\n        <div class=\"contentPart contentPart-main contentPart-main-plain_textfield trans  \">\r\n            <div class=\"contentPart_inner\">\r\n                                    <div class=\"plain_textfield text1624 \">\r\n                        <pre><strong>Mehr Informationen \u00fcber die Proben und wie Sie Kontakt zu den Partnerbiobanken von BBMRI.at aufnehmen k\u00f6nnen.\r\n<\/strong><\/pre>\n                    <\/div>\r\n                            <\/div>\r\n            <div class=\"contentPart-sidebarDummy\"><\/div>\r\n\r\n        <\/div>\r\n    <\/div>\r\n\n\n    <div id=\"links_downloadsblock_148b2a1258646a98b2d4c7c81ad37017\" class=\"content-row content-row-links_downloads  no_margin\">\r\n        <div class=\"contentPart-main contentPart-main-links_downloads trans \">\r\n            <div class=\"contentPart_inner contentPart_inner-links_downloads  flex_col\">\r\n                                    <div class=\"linkBox column\">\r\n                                                                                    <div class=\"links_inner\">\r\n                                    <div class=\"btnBox\">\r\n                                        <a href=\"https:\/\/bbmri.at\/login-intranet\/\" target=\"_self\" class=\"btnBox_inner_link btnBox_links_inner_left flex\">\r\n                                            <span class=\"main_btn_icon main_btn_icon_links_downloads\"><\/span>\r\n                                            <span class=\"main_btn_icon_hover main_btn_icon_hover_downloads\"><\/span>\r\n                                            <span class=\"main_btn_font btnBox_inner\">Suche im BBMRI Verzeichnis<\/span>\r\n                                        <\/a>\r\n                                    <\/div>\r\n                                <\/div>\r\n                                                                        <\/div>\r\n                \r\n\r\n\r\n                            <\/div>\r\n\r\n            <div class=\"contentPart-sidebarDummy\"><\/div>\r\n\r\n        <\/div>\r\n    <\/div>\r\n\n\n    <div id=\"highlightsblock_0da885de431d2829e1757a994bdf599d\" class=\"content-row content-row-highlights \">\r\n        <div class=\"contentPart-main contentPart-main-highlights trans \">\r\n            <div class=\"contentPart_inner contentPart_inner-highlights\">\r\n                <div class=\"highlights_inner\">\r\n                    <div class=\"text_highlights text1624\">\r\n                        <p><strong>oder schreiben sie ein Email an <a href=\"mailto:cornelia.stumptner@medunigraz.at\">cornelia.stumptner@medunigraz.at<\/a><\/strong><br \/>\n<strong>(Kontaktperson: Cornelia Stumptner, BBMRI.at)<\/strong><\/p>\n                    <\/div>\r\n                <\/div>\r\n            <\/div>\r\n\r\n            <div class=\"contentPart-sidebarDummy\"><\/div>\r\n        <\/div>\r\n    <\/div>\r\n\n\n    <div id=\"cohorts_indexblock_f8915eba041c76a59f39ffaa73841e8c\" class=\"content-row content-row-cohorts_index\">\r\n        <div class=\"contentPart-main contentPart-main-cohorts_index trans  \">\r\n\r\n            <div class=\"contentPart_inner contentPart_inner_cohorts_index flex_col\">\r\n\r\n                                    <h3 class=\"cohorts_index_heading text1624\">\r\n                        Einige der vielen besonderen Sammlungen werden hier beschrieben (auf Englisch)                    <\/h3>\r\n                \r\n                                                                        <div class=\"cohorts_output_index\" data-filter=\"14658\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eMilzerkrankungen bei Hunden\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An exceptional sample collection at VetBiobank Vienna (University of Veterinary Medicine, Vienna)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"15669\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLighthouse collection: Prostate cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An exceptional sample collection of the Department of Urology at Biobank Innsbruck (Med Uni Innsbruck)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6567\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eCoVVac Study: COVID-19 vaccination cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An outstanding sample collection at Biobank Graz (Med Uni Graz)                         <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6569\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLighthouse collection: COVID-19 Convalescent Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An exceptional sample collection at Biobank Graz (Med Uni Graz) which is based on a prospective sample cohort for current research on SARS-CoV-2                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6571\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLighthouse collection: Feline Lymphoma Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An exceptional sample collection at VetBiobank Vienna (University of Veterinary Medicine, Vienna)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6575\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLighthouse collection: Colorectal Cancer Whole Slide Image &#8211; Survival Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An exceptional collection by Diagnostic &amp; Research Institute of Pathology at Biobank Graz (both Med Uni Graz)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6577\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLighthouse collection: Colorectal Cancer Whole Slide Image &#8211; Vascular Invasion Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An exceptional collection by Diagnostic &amp; Research Institute of Pathology at Biobank Graz (both Med Uni Graz)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6579\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLighthouse collection: Colorectal Cancer Whole Slide Image &#8211; Clinical Annotation Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An exceptional collection by Diagnostic &amp; Research Institute of Pathology at Biobank Graz (both Med Uni Graz)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6573\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eParacelsus 10,000 Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An outstanding population-based collection at BBMRI.at partner PMU \/ SALK                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6583\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLEAD Cohort (Austrian LEAD Study)\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An outstanding collection at BBMRI.at partner MedUni Wien Biobank                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6595\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eLighthouse collection: BioPersMed Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An outstanding interdisciplinary sample collection at Biobank Graz                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6591\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201ePoCOsteo Osteoporosis Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An outstanding osteoporosis sample collection at Biobank Graz (Med Uni Graz)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6589\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201ePERFORM Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An outstanding sample collection at Biobank Graz (Med Uni Graz)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                                        <div class=\"cohorts_output_index\" data-filter=\"6585\">\r\n\r\n                        <p class=\"index_title text1624\">\r\n                            \u201eINTERFAST Cohort\u201c\r\n                        <\/p>\r\n\r\n                        <p class=\"text_addition text1624\">\r\n                            An outstanding sample collection at Biobank Graz (Med Uni Graz)                        <\/p>\r\n\r\n\r\n                    <\/div>\r\n                                            <\/div>\r\n\r\n            <div class=\"contentPart-sidebarDummy\"><\/div>\r\n\r\n        <\/div>\r\n    <\/div>\r\n\n\n    <div id=\"cohorts_displayblock_22f7abe64c3a13617f31d4a3e4ee8461\" class=\"content-row content-row-cohorts_display\">\r\n        <div class=\"contentPart-main contentPart-main-cohorts_display  \">\r\n\r\n            <div class=\"contentPart_inner contentPart_inner_cohorts_display flex_col\">\r\n                                                                <div id=\"14658\" class=\"cohorts_output trans\" data-filter=\"14658\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Milzerkrankungen bei Hunden                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            Eine au\u00dfergew\u00f6hnliche Probensammlung in der VetBiobank Wien (Veterin\u00e4rmedizinische Universit\u00e4t Wien), basierend auf einer prospektiven Kohorte von Hunden mit Milzgeschw\u00fcren, die zur Unterst\u00fctzung der aktuellen Forschung in der Veterin\u00e4ronkologie eingerichtet wurde                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p>Milzmassen, die sowohl aus gutartigen als auch aus b\u00f6sartigen Ver\u00e4nderungen entstehen k\u00f6nnen, sind bei Hunden h\u00e4ufig und zeigen ein sehr unterschiedliches klinisches Verhalten. Gutartige Tumore wie Milzh\u00e4matome und nodul\u00e4re Hyperplasien sind nicht-krebsartige Massen aus geronnenem Blut, die chirurgisch mit kurativer Absicht entfernt werden k\u00f6nnen. Im Gegensatz dazu treten b\u00f6sartige Ver\u00e4nderungen \u2013 darunter H\u00e4mangiosarkome, Lymphome und verschiedene Sarkome \u2013 oft als aggressive Tumore mit ung\u00fcnstiger Prognose auf.<\/p>\n<p>&nbsp;<\/p>\n<p>Milztumore sind besonders h\u00e4ufig bei gro\u00dfen Hunderassen. Deutscher Sch\u00e4ferhund, Golden Retriever und Labrador Retriever geh\u00f6ren zu den am st\u00e4rksten gef\u00e4hrdeten Rassen. Beim Deutschen Sch\u00e4ferhund treten zudem h\u00e4ufig hyperplastische Knoten und H\u00e4matome auf. H\u00e4mangiosarkome k\u00f6nnen jedoch Hunde jeder Rasse und Gr\u00f6\u00dfe betreffen. Kleine Hunderassen mit malignen Milzmassen haben allerdings nur ein Drittel des Risikos f\u00fcr ein H\u00e4mangiosarkom im Vergleich zu gro\u00dfen Hunderassen. Sowohl klinisch als auch histologisch ist die Unterscheidung zwischen gutartigen und b\u00f6sartigen Milztumoren h\u00e4ufig schwierig.<\/p>\n<p>&nbsp;<\/p>\n<p>Milzmassen werden oft zuf\u00e4llig entdeckt oder im Rahmen von Notf\u00e4llen infolge eines H\u00e4mabdomen diagnostiziert, was entweder zu einer dringlichen Operation oder zum Tod f\u00fchrt. Ein erheblicher Blutverlust kann dabei das Operationsrisiko zus\u00e4tzlich erh\u00f6hen. Ein diagnostischer Schnelltest am Point-of-Care k\u00f6nnte wesentlich dazu beitragen, die Art der Masse zu identifizieren und somit die Behandlungsentscheidung zwischen Operation und \u2013 leider oft \u2013 Euthanasie zu beeinflussen. Eine fr\u00fchzeitige Erkennung von Milzmassen durch routinem\u00e4\u00dfige bildgebende Diagnostik und m\u00f6glicherweise neu entwickelte Blut-Screeningtests k\u00f6nnte nicht nur Notf\u00e4lle verhindern, sondern auch eine rechtzeitige Behandlung b\u00f6sartiger F\u00e4lle erm\u00f6glichen und so die \u00dcberlebensrate verbessern.<\/p>\n<p>&nbsp;<\/p>\n<p>Als Reaktion auf diesen Bedarf wurde eine Sammlung klinischer Gewebe- und Serumproben von Hunden mit Milzmassen initiiert, um die Forschung und Entwicklung neuer diagnostischer Werkzeuge in der <strong>Veterin\u00e4r-Onkologie<\/strong> zur besseren Behandlung von Milztumoren bei Hunden zu f\u00f6rdern. Die Kohorte umfasst sowohl kastrierte als auch nicht kastrierte R\u00fcden und H\u00fcndinnen im Alter von 4 Jahren und 6 Monaten bis 16 Jahren und 1 Monat. Die Bioproben wurden gem\u00e4\u00df standardisierter Arbeitsanweisungen (SOPs) unter Einhaltung der pr\u00e4analytischen Standards f\u00fcr Gewebe CEN\/TS 16826 1-3, CEN\/TS 16827 1-3 gesammelt, um ihre Eignung f\u00fcr molekularbiologische Analysen sicherzustellen.<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Kohortenprofil: Milzerkrankungen bei Hunden<\/strong><\/pre>\n<p>&nbsp;<\/p>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Forschungsbereich                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Milzerkrankungen bei Hunden<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Probentypen                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Fixierte und native Proben von Tumor-\/pathologischem Milzgewebe (FFPE, OCT, RNAlater, Reinproben) und Serum<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Kohortengr\u00f6\u00dfe                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Insgesamt: 2021 Proben von 99 Patienten<\/li>\n<li>Sammlung l\u00e4uft seit 2016<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Spender*innen                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>unbehandelt<\/li>\n<li>Alter: 4 Jahre 6 Monate bis 16 Jahre und 1 Monat<\/li>\n<li>Geschlecht: weiblich, m\u00e4nnlich, kastriert<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Begleitdaten                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Klinische Daten (Anamnese, Therapie: Medikation, chirurgische Eingriffe, Laborbefunde, Bildgebung usw.), Probenmanagementdaten, Bilder von HE-F\u00e4rbungen<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Einwilligung                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Zustimmung durch Tierbesitzer*in<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Zugang zu                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Interner akademischer Forschung, externer akademischer Forschung, industrieller Forschung \u2013 Kooperationen bevorzugt<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Qualit\u00e4tsstandards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Gewebeproben: CEN\/TS 16826 1\u20133, CEN\/TS 16827 1\u20133<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Kontakt                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p><strong>Probenkoordination<\/strong>: VetBiobank, Ingrid Walter; Email: Ingrid.Walter@vetmeduni.ac.at<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Studienleitung<\/strong>: Brigitte Degasperi; Email: Brigitte.Degasperi@vetmeduni.ac.at<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/www.vetmeduni.ac.at\/vetcore\/research-units\/research-units\/vetbiobank\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Mehr \u00fcber die VetBioBank<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Sehen Sie sich diese und andere Kohorten von BBMRI.at-Biobanken im BBMRI-ERIC-Verzeichnis an<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"15669\" class=\"cohorts_output trans\" data-filter=\"15669\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Lighthouse collection: Prostate cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An exceptional sample collection of the Department of Urology at Biobank Innsbruck (Med Uni Innsbruck)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p>The &#8222;Prostate Cohort&#8220; is a sample collection at Biobank Innsbruck (Department of Urology, Med Uni Innsbruck). It is a collection of matched frozen tissue, FFPE tissue and blood samples of malignant and partly benign cases with associated data on histologies, certain laboratory parameters and therapies of prostate cancer specimens over the past 30 years.<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of the Prostate Cohort:<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease &amp; Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Prostate, prostate cancer, prostate benign, PSA<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Tissue, serum, urine<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>From 12,000 patients:<\/p>\n<ul>\n<li>435,000 PSA values<\/li>\n<li>8,000 tissue samples (frozen\/FFPE) (-80\u00b0C\/RT)<\/li>\n<li>180,000 serum samples (-80\u00b0C)<\/li>\n<li>1,500 urine samples (-80\u00b0C)<\/li>\n<li>4,600 radical prostatectomy (RPE) surgery data<\/li>\n<li>13,000 biopsy data<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Male<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>First line treatment surgical data with histology data of biopsy and RPE samples, follow-up data of control examinations and relapse-data, second line treatment data such as radiation, drug treatment, chemotherapy, etc. and post-treatment data<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Declaration of consent available<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Yes &#8211; in the context of a scientific cooperation<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Certified laboratory according to ISO 9001:2015<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Principle investigator: Department of Urology Innsbruck<\/p>\n<ul>\n<li>Prof. Helmut Klocker (retired)<\/li>\n<li>Dr. Martin Puhr (<a href=\"mailto:martin.puhr@i-med.ac.at\">martin.puhr@i-med.ac.at<\/a>)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research projects                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>52 projects<\/p>\n<ul>\n<li>23 of them are finished\/closed\/done<\/li>\n<li>29 of them are active or waiting to be started<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Publications                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>On average 35 publications per year.<\/p>\n<p><a href=\"https:\/\/urologielabor-innsbruck.tirol-kliniken.at\/page.cfm?vpath=publikationen-gesamtuebersicht\/publikationen--wissenschaft\" target=\"_blank\" rel=\"noopener\">List of publications of the last 10 years<\/a><\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts from BBMRI.at biobanks in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6567\" class=\"cohorts_output trans\" data-filter=\"6567\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            The CoVVac Study: COVID-19 vaccination cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An outstanding sample collection at Biobank Graz (Med Uni Graz) based on a prospective sample cohort for current research on immune response to COVID-19 vaccines in immunocompromised and healthy individuals.                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Study design<\/strong><\/p>\n<p>This study will characterize and analyze the anti-SARS-CoV-2 humoral and cellular immune response before and after vaccination with a focus on the anti-spike protein response in immunocompromised patients compared to healthy controls. Participants are invited to five visits where samples are collected and one telephone interview:<\/p>\n<ul>\n<li>1st visit (60-0 days before vaccination)<\/li>\n<li>2nd &#8222;visit&#8220; is a telephone interview to get information on vaccine reactions.<\/li>\n<li>3rd visit (+21-28 days after 2nd vaccination)<\/li>\n<li>4th visit (+6 months after 2nd vaccination)<\/li>\n<li>5th visit (+3-6 weeks after visit 4 or 3rd vaccination)<\/li>\n<li>6th visit (+6 months after visit 4)<\/li>\n<\/ul>\n<pre><strong>\r\nProfile of The CoVVac Study:<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>COVID-19<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>COVID-19 vaccination, immunocompromised, t-cell immunity, t-cell aging, antibodies<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Serum and saliva (stored at -80 \u00b0C)<\/li>\n<li>PBMC (stored in the gas phase of liquid nitrogen)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Samples will be collected from 189 immunocompromised and 187 healthy controls (6 visits planned)<br \/>\n1371 serum aliquots from 348 participants (May 2021)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Healthy<\/li>\n<li>Primary or secondary immunodeficiencies (M05, D38, M34, C90, C91.1, C92, D46)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Serology, immune status, T-cell immunity, nutritive assessment, body fat composition, BMI, date and type of COVID-19 vaccinations, vaccine reactions, medical history, current medication, smoking habits<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Broad Biobank IC (view template in <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Deutsch.pdf\" target=\"_blank\" rel=\"noopener\">German<\/a> or <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Englisch.pdf\" target=\"_blank\" rel=\"noopener\">English<\/a>), Study specific IC<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>12\/2021<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Quality management: ISO 9001:2015 (SOPs)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Principle Investigator: Assoz. Prof. Priv.-Doz. Dr.med.univ. Martin Stradner (<a href=\"mailto:biobank-pm@medunigraz.at\">biobank-pm@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Publications and press                             <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>E Schulz et al. CD19+IgD+CD27- Na\u00efve B Cells as Predictors of Humoral Response to COVID 19 mRNA Vaccination in Immunocompromised Patients; Front. Immunol., 07 December 2021, DOI: <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.803742\/full\" target=\"_blank\" rel=\"noopener\">10.3389\/fimmu.2021.803742<\/a> PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34950155\/\">34950155<\/a><\/li>\n<li>ORF Report (Wissenschaft) &#8222;<a href=\"https:\/\/steiermark.orf.at\/stories\/3134536\/\" target=\"_blank\" rel=\"noopener\">Wie wirkt CoV-Impfung bei Immunschw\u00e4che?<\/a>&#8220; (15 Dec 2021)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/#\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/biobank.medunigraz.at\/en\/for-researchers#c42505\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts at Biobank Graz website<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6569\" class=\"cohorts_output trans\" data-filter=\"6569\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Lighthouse collection: COVID-19 Convalescent Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An exceptional sample collection at Biobank Graz (Med Uni Graz) which is based on a prospective sample cohort for current research on SARS-CoV-2                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>Biobank Graz recruited participants (from Austria) who had recovered from COVID-19 and grouped them into two sub cohorts (see profile table). Volunteers were invited to fill in a questionnaire and donate various types of samples at different time points (see study design and table).<\/p>\n<p><strong>This cohort serves for<\/strong><\/p>\n<ul>\n<li>the development and validation of new antibody tests and neutralization assays<\/li>\n<li>the investigation of antibody titres over time<\/li>\n<li>a better characterization of the course of COVID-19<\/li>\n<li>the identification of diagnostic or prognostic biomarkers<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Study design<\/strong><\/p>\n<p>Participants are invited five times, i.e. 1st visit (time point 0), 2nd visit (after 1 month), 3rd visit (after 2 months), 4th visit (after 5 months), 5th visit (after 12 months), where the samples are collected. At the 1st visit, donors also fill in a questionnaire concerning symptoms, comorbidities, pre-history and lifestyle.<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of the COVID-19 Convalescent Cohort:<\/strong><\/pre>\n<p>&nbsp;<\/p>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>COVID-19<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>COVID-19 recovered patients, SARS-CoV-2, PCR test, antibody test<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Serum, EDTA buffy coat, EDTA plasma, lithium heparin plasma, sodium citrate plasma, saliva and nasopharyngeal swabs (stored at -80 \u00b0C)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>23,739 aliquots from 364 participants as of March 10th<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Volunteers who recovered from COVID-19<\/p>\n<p>Sub cohort I (342 participants):<\/p>\n<ul>\n<li>Persons who were officially tested positive for an infection by PCR test with the SARS-CoV-2 virus, showed symptoms of COVID-19 and recovered.<\/li>\n<\/ul>\n<p>Sub cohort II (22 participants):<\/p>\n<ul>\n<li>Persons who lived together or got in contact with a person officially tested positive by PCR test for SARS-CoV-2 and showed symptoms of COVID-19 disease within 14 days, but were not tested themselves, and recovered.<\/li>\n<li>Persons who showed leading COVID-19 symptoms (fever, dry cough, loss of smell or taste, diarrhoea, fatigue) since December 2019, but were not tested themselves, independent of whether they had contact to a person positive tested for SARS-CoV-2, and recovered.<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Data concerning symptoms, comorbidities, prehistory and lifestyle are collected via questionnaire<\/li>\n<li>PCR tests and antibody tests are performed<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Broad Biobank IC (view template in <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Deutsch.pdf\" target=\"_blank\" rel=\"noopener\">German<\/a> or <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Englisch.pdf\" target=\"_blank\" rel=\"noopener\">English<\/a>), Study specific IC<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                             <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>As of now<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Quality management: ISO 9001:2015 (SOPs)<\/li>\n<li>CEN\/TS 16945:2016 (metabolomics in urine, venous blood serum and plasma)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Principle Investigator: Univ.-Prof. Dr. med. univ. Robert Krause (<a href=\"mailto:biobank-pm@medunigraz.at\">biobank-pm@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Publications                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Kral S, Banfi C, Niedrist T, Sareban N, Guelly C, Kriegl L, Schiffmann S, Zurl C, Herrmann M, Steinmetz I, Schlenke P, Berghold A, Krause R. Long-lasting immune response to a mild course of PCR-confirmed SARS-CoV-2 infection: A cohort study. J Infect. 2021 Nov;83(5):607-635. doi: <a href=\"https:\/\/www.journalofinfection.com\/article\/S0163-4453(21)00419-9\/fulltext\" target=\"_blank\" rel=\"noopener\">10.1016\/j.jinf.2021.08.030<\/a>. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34433071\/\">34433071<\/a>.<\/li>\n<li>Niedrist T, Drexler C, Torreiter PP, Matejka J, Strahlhofer-Augsten M, Kral S, Riegler S, G\u00fclly C, Zurl C, Kriegl L, Krause R, Berghold A, Steinmetz I, Schlenke P, Herrmann M. Longitudinal comparison of automated SARS-CoV-2 serology assays in assessing virus neutralization capacity in COVID-19 convalescent sera. Arch Pathol Lab Med. 2022 Jan 27. doi: <a href=\"https:\/\/pubmed-1ncbi-1nlm-1nih-1gov-10013b5n3035a.han.medunigraz.at\/35085385\" target=\"_blank\" rel=\"noopener\">10.5858\/arpa.2021-0604-SA<\/a>. PMID: <a href=\"https:\/\/pubmed-1ncbi-1nlm-1nih-1gov-10013b5sx06a2.han.medunigraz.at\/35085385\/\" target=\"_blank\" rel=\"noopener\">35085385<\/a>.<\/li>\n<li>Eva M. Matzhold, G\u00fcnther F. K\u00f6rm\u00f6czi, Chiara Banfi, Marlies Sch\u00f6nbacher, Camilla Drexler, Helmberg, Ivo Steinmetz, Andrea Berghold, Peter Schlenke, Gabriel E. Wagner,<br \/>\nAnja Stoisser, Barbara Kleinhappl, Wolfgang R. Mayr and Thomas Wagner. Lower Levels of ABO Anti-A and Anti-B of IgM, IgG and IgA Isotypes in the Serum but Not the Saliva of COVID-19 Convalescents. J. Clin. Med. 2022, 11(15), 4513, doi: <a href=\"https:\/\/doi.org\/10.3390\/jcm11154513\" target=\"_blank\" rel=\"noopener\">10.3390\/jcm11154513<\/a>. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35956128\/\">35956128<\/a>.<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/biobank.medunigraz.at\/en\/for-researchers#c42505\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts at Biobank Graz website<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6571\" class=\"cohorts_output trans\" data-filter=\"6571\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Lighthouse collection: Feline Lymphoma Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An exceptional sample collection at VetBiobank Vienna (University of Veterinary Medicine, Vienna)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>Lymphoma is the most common tumor in cats. This neoplasia can develop in every tissue; however, the gastrointestinal tract is, in contrast to dogs and people, the most frequent localization in the feline species.<\/p>\n<p>The prognosis for cats suffering from intermediate or high-grade lymphoma is still poor and research in this important veterinary area continues to be under-resourced.<\/p>\n<p>The clinical cohort comprises neutered and unneutered male and female patients between 7 months and 15 years. Biospecimens are collected according to SOPs. Tissue samples are collected in line with the ISO standards 20166 and 20184 and are therefore suitable for molecular investigations.<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of the feline lymphoma cohort:<\/strong><\/pre>\n<p>&nbsp;<\/p>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Lymphoma in cats<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Fixed and native samples from tumor and healthy reference tissues (FFPE, glutaraldehyde for electron microscopy, OCT, RNAlater, pure), serum, plasma, urine, feces<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Complete set of samples and data with follow up examination for 36 patients available; collection start February 2016 &#8211; collection ongoing<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>untreated, treated<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Clinical data (anamnesis, treatment: medication, surgical intervention, laboratory results, imaging data, &#8230;), sample management data, images from HE stains<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Approved by the patient owner<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Internal academic research, external academic research, industrial research &#8211; cooperation preferred<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Tissue samples were collected according to the sample pre-analytics standards: CEN\/TS 16826 1-2, CEN\/TS 16827 1-3<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Sample Coordinator: VetBiobank, Ingrid Walter (<a href=\"mailto:ingrid.walter@vetmeduni.ac.at\">ingrid.walter@vetmeduni.ac.at<\/a>)<\/li>\n<li>Principle investigator: Birgitt Wolfesberger (<a href=\"mailto:birgitt.wolfesberger@vetmeduni.ac.at\">birgitt.wolfesberger@vetmeduni.ac.at<\/a>)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other clinical veterinary cohorts (BBMRI Directory)<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View cohorts from VetBioBank and other BBMRI.at partner biobanks in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/www.vetmeduni.ac.at\/vetcore\/research-units\/research-units\/vetbiobank\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Mehr Info zur VetBioBank<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                                            <div class=\"part_img_cohorts\">\r\n                                                        <img decoding=\"async\" src=\"https:\/\/bbmri.at\/wp-content\/uploads\/2023\/09\/Feline-Lymphoma-Cohort-1110x181.png\" alt=\"\" class=\"img_datafield\">\r\n                        <\/div>\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6575\" class=\"cohorts_output trans\" data-filter=\"6575\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Lighthouse collection: Colorectal Cancer Whole \r\nSlide Image &#8211; Survival Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An exceptional collection by Diagnostic &amp; Research Institute of Pathology at Biobank Graz (both Med Uni Graz)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>The \u201eColorectal Cancer Cohort (CRC-Cohort)\u201c is a huge collection of colorectal cancer resection samples from the Institute of Pathology located at Biobank Graz at the Medical University of Graz. It consists of various CRC sub-cohorts from colorectal cancer tissue with associated H&amp;E, histological and immunhistochemical stainings where samples have been analysed and supplemented by digital images of tissue slides in various projects.<\/p>\n<p>A very well researched sub-cohort is the \u201eColorectal cancer whole slide image cohort\u201c (CRC WSI cohort) which consists of 3 parts, i.e.:<\/p>\n<p>1. \u201eCRC whole slide image &#8211; survival cohort\u201c<br \/>\n2. \u201eCRC whole slide image &#8211; vascular invasion cohort\u201c<br \/>\n3. \u201eCRC whole slide image \u2013 clinical annotation cohort\u201c<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of (1) \"CRC whole slide image - survival cohort\": \r\n<b>This cohort was\/is part of several industrial research collaborations e.g. with Google and Roche Diagnostics<\/b><\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Colorectal cancer \/ ICD-10: C18.0<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Colorectal cancer, survival prediction, artificial intelligence, etc.<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>H&amp;E stained FFPE tissue slides (RT storage)<\/li>\n<li>Immunohistochemistry (IHC) on FFPE tissue slides (RT storage)<\/li>\n<li>Whole slide images of H&amp;E and IHC FFPE tissue slides<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Over 180,000 images (resolution 0.25\u00b5m\/pixel, over 800 TByte) from 100,000 slides (H&amp;E and IHC staining of FFPE tissue sections) from over 6,400 cases comprising tissue from colorectal cancer resections (tumour and non-tumour colon tissue, resection margins, fatty tissue, and associated lymph nodes)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Inclusion criteria:<\/p>\n<ul>\n<li>Patients with colorectal cancer as a primary diagnosis (C18), samples from 1984 to 2013<\/li>\n<li>Patient age: 18 \u2013 100 years<\/li>\n<li>Tumour stages: II to III<\/li>\n<li>Ratio female : male = 45:55<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Pathology diagnosis<\/li>\n<li>TNM staging<\/li>\n<li>ICD-10 and ICD-O codes<\/li>\n<li>Survival data<\/li>\n<li>Meta data from whole slide images<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Depending on year of collection with or without informed consent<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Access for collaborative research projects depending on ethics committee approval from the Medical University of Graz<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>ISO 9001:2015 (Biobank Graz)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Publications and press (examples)                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Wulczyn E, Steiner DF, Moran M, Plass M, Reihs R, Tan F, Flament-Auvigne I, Brown T, Regitnig P, Chen PC, Hegde N, Sadhwani A, MacDonald R, Ayalew B, Corrado GS, Peng LH, Tse D, M\u00fcller H, Xu Z, Liu Y, Stumpe MC, Zatloukal K: Interpretable survival prediction for colorectal cancer using deep learning. Mermel CH. NPJ Digit Med. 2021 Apr 19;4(1):71. DOI: <a href=\"https:\/\/www.nature.com\/articles\/s41746-021-00427-2\" target=\"_blank\" rel=\"noopener\">10.1038\/s41746-021-00427-2<\/a>, PMID: <a href=\"https:\/\/pubmed-1ncbi-1nlm-1nih-1gov-10013b5sx06a2.han.medunigraz.at\/33875798\/\" target=\"_blank\" rel=\"noopener\">33875798<\/a>.<\/li>\n<li>L&#8217;Imperio V, Wulczyn E, Plass M et al.: Pathologist Validation of a Machine Learning-Derived Feature for Colon Cancer Risk Stratification. JAMA Netw Open. 2023;6(3):e2254891. DOI:<a href=\"https:\/\/doi-1org-10013b52v025f.han.medunigraz.at\/10.1001\/jamanetworkopen.2022.54891\" target=\"_blank\" rel=\"noopener\">10.1001\/jamanetworkopen.2022.54891<\/a>, PMID:\u00a0<a href=\"https:\/\/pubmed-1ncbi-1nlm-1nih-1gov-10013b52v025f.han.medunigraz.at\/36917112\/\" target=\"_blank\" rel=\"noopener\">36917112<\/a><\/li>\n<li>Media article about research collaboration of Med Uni Graz and Google on revolutionary findings with relevance for diagnostics: algorithms are declaring war on cancer (Kleine Zeitung 2021)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Projects                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Industry collaboration<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Univ.-Prof. Dr. med. univ. Kurt Zatloukal (<a href=\"mailto:kurt.zatloukal@medunigraz.at\">kurt.zatloukal@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/#\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Find the overall Colorectal Cancer Cohort in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/www.euronews.com\/next\/2019\/01\/14\/european-researchers-tackle-cancer-with-biobanks\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View video on ADOPT BBMRI-ERIC &amp; Colorectal Cancer (Euronews)<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/www.youtube.com\/watch?v=8yeCAMMJyHk&#038;t=2s\" target=\"_self\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View video on Colorectal Cancer Cohort with two experts from BBMRI.at<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6577\" class=\"cohorts_output trans\" data-filter=\"6577\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Lighthouse collection: Colorectal Cancer Whole \r\nSlide Image &#8211; Vascular Invasion Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An exceptional collection by Diagnostic &amp; Research Institute of Pathology at Biobank Graz (both Med Uni Graz)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>The \u201eColorectal Cancer Cohort (CRC-Cohort)\u201c is a huge collection of colorectal cancer resection samples from the Institute of Pathology located at Biobank Graz at Medical University of Graz. It consists of various CRC sub-cohorts from colorectal cancer tissue with associated H&amp;E, histological and immunhistochemical stainings where samples have been analysed and supplemented by digital images of tissue slides in various projects.<\/p>\n<p>A very well researched sub-cohort is the \u201eColorectal cancer whole slide image cohort\u201c (CRC WSI cohort) which consists of 3 parts, i.e.:<\/p>\n<p>1. \u201eCRC whole slide image &#8211; survival cohort\u201c<br \/>\n2. \u201eCRC whole slide image &#8211; vascular invasion cohort\u201c<br \/>\n3. \u201eCRC whole slide image \u2013 clinical annotation cohort\u201c<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of (2) \"CRC whole slide image - vascular invasion cohort\":\r\n<b>Sub-collection of the CRC collection that was part of the EU H2020 project ADOPT BBMRI-ERIC (<\/b>grant agreement number:\u00a0676550<b>)<\/b>\r\n<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Colorectal cancer \/ ICD-10: C18.0<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Colorectal cancer, survival prediction, artificial intelligence, etc.<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>H&amp;E stained FFPE tissue slides (RT storage)<\/li>\n<li>(Immuno)histochemistry (IHC) on FFPE tissue slides, Elastica van Giesson staining, vascular endothelial marker IHC (CD-31) (RT storage)<\/li>\n<li>Whole slide images of H&amp;E and IHC FFPE tissue slides<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Approx. 800 whole slide images (resolution 0.25\u00b5m\/pixel) from ~ 800 slides (H&amp;E, histochemical and IHC staining of FFPE tissue sections) from over 260 cases comprising colorectal tumour tissue<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Inclusion criteria:<\/p>\n<ul>\n<li>Patients with colorectal cancer as a primary diagnosis (C18), samples from 1984 to 2013<\/li>\n<li>Patient age: 18 \u2013 100 years<\/li>\n<li>Tumour stages: I to IV<\/li>\n<li>Female, male<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data*                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Pathology diagnosis<\/li>\n<li>TNM staging<\/li>\n<li>ICD-10 and ICD-O codes<\/li>\n<li>Clinical data<\/li>\n<li>Survival data<\/li>\n<li>Meta data from whole slide images<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Depending on year of collection with or without informed consent<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Access for collaborative research projects depending on ethics committee approval from the Medical University of Graz<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>ISO 9001:2015 (Biobank Graz)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Univ.-Prof. Dr. med. univ. Kurt Zatloukal (<a href=\"mailto:kurt.zatloukal@medunigraz.at\">kurt.zatloukal@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Projects                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Sub-collection of the CRC collection that was part of the EU H2020 project ADOPT BBMRI-ERIC (grant agreement number 676550)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/#\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Find the overall Colorectal Cancer Cohort in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/www.euronews.com\/next\/2019\/01\/14\/european-researchers-tackle-cancer-with-biobanks\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View video on ADOPT BBMRI-ERIC &amp; Colorectal Cancer (Euronews)<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/www.bbmri-eric.eu\/scientific-collaboration\/colorectal-cancer-cohort\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Find details about the European CRC Cohort here<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6579\" class=\"cohorts_output trans\" data-filter=\"6579\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Lighthouse collection: Colorectal Cancer Whole \r\nSlide Image &#8211; Clinical Annotation Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An exceptional collection by Diagnostic &amp; Research Institute of Pathology at Biobank Graz (both Med Uni Graz)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>The \u201eColorectal Cancer Cohort (CRC-Cohort)\u201c is a huge collection of colorectal cancer resection samples from the Institute of Pathology located at Biobank Graz at Medical University of Graz. It consists of various CRC sub-cohorts from colorectal cancer tissue with associated H&amp;E, histological and immunhistochemical stainings where samples have been analysed and supplemented by digital images of tissue slides in various projects.<\/p>\n<p>A very well researched sub-cohort is the \u201eColorectal cancer whole slide image cohort\u201c (CRC WSI cohort) which consists of 3 parts, i.e.:<\/p>\n<p>1. \u201eCRC whole slide image &#8211; survival cohort\u201c<br \/>\n2. \u201eCRC whole slide image &#8211; vascular invasion cohort\u201c<br \/>\n3. \u201eCRC whole slide image \u2013 clinical annotation cohort\u201c<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of (3) \"CRC whole slide image - clinical annotation cohort\":\r\n<b>Sub-collection of the CRC collection that was part of the EU H2020 project ADOPT BBMRI-ERIC (<\/b>grant agreement number:\u00a0676550<b>)<\/b>\r\n<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Colorectal cancer \/ ICD-10: C18.0<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Colorectal cancer, survival prediction, artificial Intelligence, etc.<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>H&amp;E stained FFPE tissue slides (RT storage)<\/li>\n<li>Immunohistochemistry (IHC) on FFPE tissue slides (RT storage)<\/li>\n<li>Whole slide images of H&amp;E and IHC FFPE tissue slides<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Approx. 1,800 whole slide images (resolution 0.25\u00b5m\/pixel) from ~800 slides (H&amp;E and IHC staining of FFPE tissue sections) from over 100 cases comprising tissue from colorectal cancer resections (tumour and non-tumour colon tissue, resection margins, fatty tissue, and associated lymph nodes)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Inclusion criteria:<\/p>\n<ul>\n<li>Patients with colorectal cancer as a primary diagnosis (C18), samples from 1984 to 2013<\/li>\n<li>Age: 18 \u2013 100 years<\/li>\n<li>Stages: II and III<\/li>\n<li>Female, male<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data*                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Pathology diagnosis<\/li>\n<li>TNM staging<\/li>\n<li>ICD-10 and ICD-O codes<\/li>\n<li>Clinical data<\/li>\n<li>Survival data<\/li>\n<li>Meta data from whole slide images<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Depending on year of collection with or without informed consent<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Access for collaborative research projects depending on ethics committee approval from the Medical University of Graz<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>ISO 9001:2015 (Biobank Graz)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Univ.-Prof. Dr. med. univ. Kurt Zatloukal (<a href=\"mailto:kurt.zatloukal@medunigraz.at\">kurt.zatloukal@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Projects                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Sub-collection of the CRC collection that was part of the EU H2020 project ADOPT BBMRI-ERIC (grant agreement number 676550)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/#\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Find the overall Colorectal Cancer Cohort in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/www.euronews.com\/next\/2019\/01\/14\/european-researchers-tackle-cancer-with-biobanks\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View video on ADOPT BBMRI-ERIC &amp; Colorectal Cancer (Euronews)<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/www.bbmri-eric.eu\/scientific-collaboration\/colorectal-cancer-cohort\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Find details about the European CRC Cohort here<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n                        <div class=\"cohorts_textfield cohorts_textfield_two text1624\">\r\n                            <pre>*Data associated with ADOPT CRC Cohort:<\/pre>\n<ul>\n<li>Sex<\/li>\n<li>Participation in clinical study (yes\/no)<\/li>\n<li>Age at primary diagnosis<\/li>\n<li>Time of recurrence (metastasis)<\/li>\n<li>Family history\u00a0of cancer<\/li>\n<li>Other diseases: other cancers, inflammatory bowel disease, intestinal polyps, other disease requiring therapy (e.g., cardio-vascular, endocrine. musculoskeletal)<\/li>\n<li>Tumor markers (e.g., CEA) (if available)<\/li>\n<li>Vital status and survival information: timestamp of last update of vital status, overall survival status<\/li>\n<li>Surgery: time difference between initial diagnosis and surgery, surgery radicality, type of surgery<\/li>\n<li>Pharmacotherapy (REQUIRED if occurred): start of pharmacotherapy (relative date referring to the primary diagnosis), scheme of pharmacotherapy<\/li>\n<li>Targeted therapy (REQUIRED if occurred): start of targeted therapy (relative date referring to the primary diagnosis), end of targeted therapy (relative date referring to the primary diagnosis)<\/li>\n<li>Radiation therapy (REQUIRED if occurred): start of radiotherapy (relative date referring to the primary diagnosis), end of radiotherapy (relative date referring to the primary diagnosis)<\/li>\n<li>Response to therapy: specific response; the response is linked to the patient and specified by a timestamp. This is to avoid the need of specifying to which therapy the response belongs, since there might be a combination of different therapies<\/li>\n<li>Molecular markers (if available): microsatellite instability, mismatch repair gene expression \u2013 IHC array for different genes (common for 3; if applicable), risk situation (only HNPCC), RAS mutation status (if applicable), BRAF, PIC3CA. HER2 mutation status (optional)<\/li>\n<li>Histopathology: pTNM, UICC staging, WHO grading, histological classification (according to WHO), localization of the tumor, high resolution digital images (resolution &lt; 0.25 Microns\/pixel) of the tumor, resection margin and lymph nodes<\/li>\n<li>Diagnostic exam: result of colonoscopy, array of diagnostic methods (results of liver imaging, lung imaging, MRI, CT; if occurred)<\/li>\n<\/ul>\n                        <\/div>\r\n\r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6573\" class=\"cohorts_output trans\" data-filter=\"6573\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Paracelsus 10,000 Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An outstanding population-based collection at BBMRI.at partner Uniklinikum Salzburg (Landeskrankenhaus Salzburg\/Universit\u00e4tsklinikum der PMU)                         <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>Paracelsus 10,000 Cohort is a population-based collection from 5,000 male and 5,000 female probands from Salzburg (Austria). It comprises numerous different types of samples and data from diverse analyses and different follow up visits.<\/p>\n<p><strong>The purpose of this cohort is to serve the following study aims:<\/strong><\/p>\n<ul>\n<li>Collection of valid epidemiological data on the state of health of the Salzburg population<\/li>\n<li>Clarification of the interaction of genetic disposition and lifestyle factors in the development of degenerative diseases<\/li>\n<li>Development of well-directed prevention processes for the population of Salzburg<\/li>\n<li>Strengthening of the research location Salzburg and Austria<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of the Paracelsus 10,000 Cohort:<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Plasma (EDTA, citrate and heparin), serum, EDTA blood for DNA isolation, buffy coat, urine, stool samples<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Representative sample of 10 000 participants (5.000 male, 5.000 female) by 03\/2020<\/p>\n<ul>\n<li>40-49 years: 2700 participants<\/li>\n<li>50-59 years: 4300 participants<\/li>\n<li>60-69 years: 3000 participants<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>From the city of Salzburg and surrounding townships<br \/>\nMale-female ratio 1:1<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>1. Basic investigations of all participants:<\/p>\n<ul>\n<li>Questionnaires on diet, exercise, socio-economic anamnesis, depression, cognitive performance, quality of life, stress and environmental factors<\/li>\n<li>Anthropometry: height, weight, abdominal girth<\/li>\n<li>Resting blood pressure, heart rate, resting 12-channel ECG<\/li>\n<li>Laboratory parameters: Lipid profile, Apo-B, Apo-AI, Lp(a), FBS, HbA1c, Electrolytes, CR, Urea, LFT, Fe-Status, hsCRP, fibrinogen, BC, TSH, PSA (men), Fasting-Insulin<\/li>\n<li>Urine: chemistry, albumin\/creatinine ratio<\/li>\n<li>Ultrasound of the carotides<\/li>\n<\/ul>\n<p>2. Additional investigations for the intensively phenotyped subgroup (50 to 59 years):<\/p>\n<ul>\n<li>Laboratory parameters: fasting proinsulin, free fatty acids, adiponectin, vitamin D<\/li>\n<li>Determination of insulin sensitivity and beta cell function by frequently sampled OGTT (with simultaneous determination of insulin, C-peptide and blood glucose at the time points 0 min., 30 min., 60 min., 90 min. and 120 min.)<\/li>\n<li>Pulmonary function test<\/li>\n<li>Pulse wave analysis<\/li>\n<li>Multi-frequency body composition B.I.A.<\/li>\n<li>Measurement of intima-media thickness and plaque score of carotid arteries<\/li>\n<li>Measurement of the coronary artery calcium score<\/li>\n<li>24h blood pressure measurement<\/li>\n<li>7-day nutrition protocol<\/li>\n<li>7-day movement monitoring using movement sensors<\/li>\n<li>Ankle-brachial index<\/li>\n<li>Hand grip<\/li>\n<li>6 meter walking test<\/li>\n<\/ul>\n<p>3. Additional investigations for two participants per day (50 to 59 years):<\/p>\n<ul>\n<li>Coronary Ca-score<\/li>\n<li>Body fat distribution and bone density (measured with DEXA-scan)<\/li>\n<li>Ergospirometry<\/li>\n<li>Ultrasound of the liver<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Prof. Dr. Bernhard Paulweber (<a href=\"mailto:b.paulweber@salk.at\">b.paulweber@salk.at<\/a>)<\/li>\n<li>Dr. Ludmilla Kedenko PhD (<a href=\"mailto:l.kedenko@salk.at\">l.kedenko@salk.at<\/a>)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Publications                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Vanessa Natalie Frey, Patrick Langthaler, Emanuel Raphaelis et al. Paracelsus 10,000: A Prospective Cohort Study Based On The Population of Salzburg, Austria. Rationale, Objectives And Study Design, 17 August 2021, PREPRINT (Version 1). doi: <a href=\"https:\/\/www.researchsquare.com\/article\/rs-740574\/v1\" target=\"_blank\" rel=\"noopener\">10.21203\/rs.3.rs-740574\/v1<\/a>.<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/salk.at\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View details at SALK website<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/bbmri.at\/wp-content\/uploads\/2023\/10\/2020-07_Paracelsus-10.000-Population-Cohort_PMU-SALK.pdf\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View details (pdf)<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6583\" class=\"cohorts_output trans\" data-filter=\"6583\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            LEAD Cohort (Austrian LEAD Study)                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An outstanding collection at BBMRI.at partner MedUni Wien Biobank                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>The Biobank of the Medical University of Vienna harbours the sample cohort of the &#8222;Austrian LEAD-Study&#8220; collected at the Ludwig Bolzmann Institute. It is a population based cohort and one of the largest long-term studies in Austria on the topic of lung health.<\/p>\n<p>The Lung, hEart, sociAl, boDy (LEAD) Study is a longitudinal, observational, epidemiological cohort study aiming to investigate respiratory health through life. The survey includes a representative sample of the Austrian general population between 6 and 80 years of age and focuses on three areas:<\/p>\n<ul>\n<li>Normal and pathologic lung growth and development (natural history of lung function).<\/li>\n<li>Genetic, environmental and socioeconomic risk factors for abnormal lung function.<\/li>\n<li>Extrapulmonary manifestations of abnormal lung function and related comorbidities (cardiovascular disease, metabolic disorders, depression and anxiety).<\/li>\n<\/ul>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/lunghealth.lbg.ac.at\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Ludwig Bolzmann Institute for Lung Health<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/leadstudy.at\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">Current status and examination programme<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/pathologie.meduniwien.ac.at\/biobank\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">More about MedUni Wien Biobank<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30344197\/\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">More about the LEAD cohort<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                                            <div class=\"part_img_cohorts\">\r\n                                                        <img decoding=\"async\" src=\"https:\/\/bbmri.at\/wp-content\/uploads\/2023\/09\/LEAD-Study-1110x135.jpg\" alt=\"\" class=\"img_datafield\">\r\n                        <\/div>\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6595\" class=\"cohorts_output trans\" data-filter=\"6595\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            Lighthouse collection: BioPersMed Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An outstanding interdisciplinary sample collection at Biobank Graz                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>&#8222;BioPersMed&#8220; stands for &#8222;Biomarkers for Personalised Medicine in Common Metabolic Disorders.<\/p>\n<p>This prospectively collected cohort comprises a huge number of samples and data being collected and used since 2010 (still ongoing). Its aim is to detect and define specific characteristics and personalized biomarkers of patients at risk for cardiovascular and metabolic diseases and to follow them for future developments.<\/p>\n<p>The &#8222;BioPersMed Cohort&#8220; includes the research areas endocrinology &amp; metabolism and cardiology. Diabetes, fatty liver disease, osteoporosis or cardiovascular diseases are only some of the topics in the focus of this cohort.<\/p>\n<p>The samples meet the requirements of the sample quality standards &#8222;CEN\/TC 140 Molecular in vitro diagnostic examinations &#8211; Specifications for preexamination processes (CEN\/TS) for metabolomics in urine, venous blood serum and plasma&#8220; (CEN\/TS 16945:2016) that were published by the European Committee for Standardization (CEN).<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of the BioPersMed Cohort:<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Diabetes, fatty liver disease, osteoporosis, cardiovascular diseases<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Biomarker, endocrinology, metabolism, cardiology<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Plasma (EDTA, Lithium Heparin, Sodium Citrate), serum, buffy coat; urine, 24h urine of healthy and diseased patients<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>1,024 probands (in 4 follow-up visits): healthy and diseased<\/li>\n<li>&gt;220,000 aliquots (as per March 2018)<br \/>\ncollection ongoing<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Healthy and diseased<\/li>\n<li>Age: adults 35+ years<\/li>\n<li>Gender: 50\/50 female\/male<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Clinical records\/diagnosis, smoking and lifestyle anamnesis, follow-up laboratory results, follow-up clinical data<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Broad Biobank IC (view template in <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Deutsch.pdf\" target=\"_blank\" rel=\"noopener\">German<\/a> or <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Englisch.pdf\" target=\"_blank\" rel=\"noopener\">English<\/a>) &amp; specific study IC<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Cooperation only<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Sample quality: <a href=\"https:\/\/www.din.de\/en\/meta\/search\/61764!search?query=CEN%2FTS+16945%3A2016+-+Molecular+in+vitro+diagnostic+examinations.+Specifications+for+pre-examination+processes+for+metabolomics+in+urine%2C+venous+blood+serum+and+plasma\" target=\"_blank\" rel=\"noopener\">CEN\/TS 16945:2016 &#8211; Molecular in vitro diagnostic examinations. Specifications for pre-examination processes for metabolomics in urine, venous blood serum and plasma<\/a><\/li>\n<li>Quality management: ISO 9001:2015 (SOPs)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Scientific director: Barbara Obermayer-Pietsch (<a href=\"mailto:barbara.obermayer@medunigraz.at\">barbara.obermayer@medunigraz.at<\/a>)<\/li>\n<li>Partners: Thomas Pieber, Karine Sargsyan, Albrecht Schmidt (<a href=\"mailto:biobank-pm@medunigraz.at\">biobank-pm@medunigraz.at<\/a>)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Kohorten\/BioPersMed-Cohort-Article.pdf\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">More details about the BioPersMed Cohort<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                                            <div class=\"part_img_cohorts\">\r\n                                                        <img decoding=\"async\" src=\"https:\/\/bbmri.at\/wp-content\/uploads\/2025\/10\/Logoband.png\" alt=\"\" class=\"img_datafield\">\r\n                        <\/div>\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6591\" class=\"cohorts_output trans\" data-filter=\"6591\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            PoCOsteo Osteoporosis Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An outstanding osteoporosis sample collection at Biobank Graz (Med Uni Graz)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>&#8222;PoCOsteo&#8220; stands for Point-of-care in-office device for identifying individuals at high risk of Osteoporosis and osteoporotic fracture.<\/p>\n<p>The data is being collected (starting May 2018) in the context of the HORIZON 2020 project PoCOsteo (Proposal number 767325) which aims at developing point-of-care in-vitro devices to measure and\/or quantify proteomic and genomic factors in human whole blood.<\/p>\n<p>The clinical cohort includes male and female patients fifty years and above and ranges from healthy (per definition) to those who experienced multiple fragility fractures due to secondary osteoporosis.<\/p>\n<p>It comprises untreated patients as well as those treated for osteoporosis, with or without concomitant diseases such as hypertension, diabetes etc.<\/p>\n<p>The samples meet the requirements of the sample quality standards &#8222;CEN\/TC 140 Molecular in vitro diagnostic examinations &#8211; Specifications for preexamination processes (CEN\/TS) for metabolomics in urine, venous blood serum and plasma&#8220; (CEN\/TS 16945:2016) that were published by the European Committee for Standardization (CEN).<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of the PoCOsteo Cohort:<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Endocrinology, osteoporosis, osteoporotic fractures<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Biomarker development &amp; detection<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Serum, EDTA-plasma and buffy coat (stored at -80\u00b0C)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>1,000 probands<\/p>\n<p>Collection start in May 2018 &#8211; collection ongoing<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Healthy and diseased, treated and untreated for osteoporosis with or without concomitant diseases (e.g. hypertension, diabetes, \u2026)<\/li>\n<li>Age: adults &gt; 50 years<\/li>\n<li>Gender: female and male<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>From the following time-points:<\/p>\n<ul>\n<li>study inclusion<\/li>\n<li>after 12 months<\/li>\n<li>possibly after 24 months<\/li>\n<\/ul>\n<p>Bone mineral density (BMD) of the hip and the lumbar spine as well as vertebral fracture assessment (VFA) by Dual X-ray absorptiometry (DXA), grip strength (hydraulic hand dynamometer), and a routine blood test including renal and hepatic parameters together with a lipid profile<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Broad Biobank IC (view template in <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Deutsch.pdf\" target=\"_blank\" rel=\"noopener\">German<\/a> or <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Englisch.pdf\" target=\"_blank\" rel=\"noopener\">English<\/a>), specific study IC<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Cooperation preferred<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Sample quality: <a href=\"https:\/\/www.din.de\/en\/meta\/search\/61764!search?query=CEN%2FTS+16945%3A2016+-+Molecular+in+vitro+diagnostic+examinations.+Specifications+for+pre-examination+processes+for+metabolomics+in+urine%2C+venous+blood+serum+and+plasma\" target=\"_blank\" rel=\"noopener\">CEN\/TS 16945:2016 &#8211; Molecular in vitro diagnostic examinations. Specifications for pre-examination processes for metabolomics in urine, venous blood serum and plasma<\/a><\/li>\n<li>Quality management: ISO 9001:2015 (SOPs)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Principle Investigator: Hans Dimai, Medical University of Graz, Department of Internal Medicine, Division of Endocrinology and Metabolism (<a href=\"mailto:biobank-pm@medunigraz.at\">biobank-pm@medunigraz.at<\/a>, <a href=\"mailto:hans.dimai@medunigraz.at\">hans.dimai@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Kohorten\/PoCOsteo-Study-Article.pdf\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">More details about the PoCOsteo Cohort<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Kohorten\/PoCOsteo-Study.pdf\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View PoCOsteo cohort profile form (Biobank Graz)<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                                            <div class=\"part_img_cohorts\">\r\n                                                        <img decoding=\"async\" src=\"https:\/\/bbmri.at\/wp-content\/uploads\/2023\/09\/PoCOsteo-Cohort-1110x129.jpg\" alt=\"\" class=\"img_datafield\">\r\n                        <\/div>\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6589\" class=\"cohorts_output trans\" data-filter=\"6589\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            PERFORM Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An outstanding sample collection at Biobank Graz (Med Uni Graz)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>&#8222;PERFORM&#8220; stands for Personalised Risk assessment in Febrile illness to Optimise Real-life Management across the European Union. It represents a pediatric cohort of samples from children and is collected in the context of the PERFORM EU Horizon 2020 project.<\/p>\n<p>The collection aims to improve the diagnostics in febrile children and adolescents and to develop a comprehensive management plan for febrile patients in Europe. It helps to improve the diagnostics in febrile children and adolescents.<\/p>\n<p>The &#8222;PERFORM cohort&#8220; comprises PAXgene stabilized and EDTA blood samples (whole blood, plasma, pellet), cerebrospinal fluid, throat swab, urine and stool. It includes children below the age of 18 (both genders) with i) fever &gt;38\u00baC, or a history of fever (within 3 days), or ii) suspected of infection.<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of PERFORM Cohort:<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Disease Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Febrile illness<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>ETDA blood (plasma, pellet and whole blood), blood in PAXgene tubes, cerebrospinal fluid, throat swab, urine, and stool stored at -80\u00b0C<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Samples from 500 patients<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Children &lt;18 years<\/p>\n<ul>\n<li>with fever &gt;38\u00baC, or a history of fever (within 3 days), in whom the attending clinician determines the need for blood sampling or whom parents give consent for blood taken for research purposes<\/li>\n<li>suspected of infection (included: full spectrum of disease severity, and with co-morbidities)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Specific study IC<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Cooperation only<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Quality management: ISO 9001:2015 (SOPs)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Publications and press                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>ORF Report <a href=\"https:\/\/steiermark.orf.at\/stories\/3033295\/\" target=\"_blank\" rel=\"noopener\">&#8222;Lebensbedrohlich krank: Neuer Schnelltest&#8220;<\/a><\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Principle Investigator: Univ. Prof. Dr. Werner Zenz, Pediatric and Adolescent University Hospital, Department of General Pediatrics Medical University of Graz (<a href=\"mailto:perform@medunigraz.at\">perform@medunigraz.at<\/a>, <a href=\"mailto:biobank-pm@medunigraz.at\">biobank-pm@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Kohorten\/PERFORM-Collection-Article.pdf\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">More details about the PERFORM cohort<\/span>\r\n                            <\/a>\r\n                                                    <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Kohorten\/PERFORM-Collection.pdf\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View cohort profile (Biobank Graz)<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                                            <div class=\"part_img_cohorts\">\r\n                                                        <img decoding=\"async\" src=\"https:\/\/bbmri.at\/wp-content\/uploads\/2023\/09\/PERFORM-Cohort-1110x129.jpg\" alt=\"\" class=\"img_datafield\">\r\n                        <\/div>\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                                <div id=\"6585\" class=\"cohorts_output trans\" data-filter=\"6585\">\r\n\r\n                    <div class=\"textfield_part\">\r\n                        <h3 class=\"cohorts_headline\">\r\n                            INTERFAST Cohort                        <\/h3>\r\n\r\n                        <h4 class=\"cohorts_subheadline\">\r\n                            An outstanding sample collection at Biobank Graz (Med Uni Graz)                        <\/h4>\r\n\r\n                        <div class=\"cohorts_textfield text1624\">\r\n                            <p><strong>Summary<\/strong><\/p>\n<p>&#8222;INTERFAST&#8220; stands for Intermittent Fasting (i.e. a dietary regimen of alternating fasting and &#8222;feeding&#8220; cycles, e.g. practised by alternate day fasting). The INTERFAST collection represents a cohort of blood and urine samples from healthy donors who have undergone different types of intermittent fasting and is collected in the context of the INTERFAST project.<\/p>\n<p>The cohort supports studies that aim to investigate the effects of repeating fasting periods on human physiology, aging process and molecular cellular processes in humans.<\/p>\n<p>This includes both studying<\/p>\n<ul>\n<li>long term effects of fasting (as donors are included in the cohort who already practice alternate day fasting (ADF) for a defined time period) as well as<\/li>\n<li>short term effects of this nutritional intervention (i.e. intermittent fasting)<\/li>\n<\/ul>\n<p>The INTERFAST cohort comprises serum, plasma and urine samples.<\/p>\n<p>&nbsp;<\/p>\n<pre><strong>Profile of the INTERFAST Cohort:<\/strong><\/pre>\n                        <\/div>\r\n\r\n                    <\/div>\r\n\r\n                                        <div class=\"datafield_output\">\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Research Area                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Intermittent fasting, alternate day fasting (ADF), effects on autophagy, human physiology, aging process and molecular-cellular processes<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Sample Types                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Serum, plasma and urine samples stored at -80\u00b0C<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Cohort Size                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>90 donors:<\/p>\n<ul>\n<li>30 subjects cohort &#8211; 2 study visits<\/li>\n<li>60 subjects RCT &#8211; 4 study visits<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Donors                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Cohort (alternate day fasting for at least 6 months before the start of the trial \u2013 30 subjects) as well as randomized control-trial (60 subjects \u2013 randomized to either intervention group (alternate day fasting) or control group with no intervention 1:1).<\/p>\n<ul>\n<li>Adults 35 &#8211; 65 years; ratio female:male = 57:43<br \/>\nFurther inclusion criteria:<\/li>\n<li>Body mass index in the range of 22.0 \u2013 30.0 kg\/m2<\/li>\n<li>Fasting blood glucose &lt;110mg\/dL (without medication)<\/li>\n<li>LDL-cholesterol &lt;180 mg\/dL (without medication)<\/li>\n<li>Blood pressure &lt;140\/90 mmHg (without medication)<\/li>\n<li>Stable weight (change &lt;\u00b1 10%) for 3 months immediately<\/li>\n<\/ul>\n<p>Exclusion criteria: see <a href=\"https:\/\/bbmri.at\/wp-content\/uploads\/2023\/10\/Cohort-Profile-BBMRI.at_BBG_5010_14_INTERFAST_Endokrinologie_Sourij_Langtext_V4_neu.pdf\" target=\"_blank\" rel=\"noopener\">INTERFAST cohort details<\/a><\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Associated Data                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <ul>\n<li>Demographics<\/li>\n<li>Medical history<\/li>\n<li>Concomitant medication<\/li>\n<li>Vital signs<\/li>\n<li>Physical examination<\/li>\n<li>Blood sampling with oral glucose tolerance test (oGTT)<\/li>\n<li>Electrocardiogram (ECG)<\/li>\n<\/ul>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Informed Consent                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Broad Biobank IC (view template in <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Deutsch.pdf\" target=\"_blank\" rel=\"noopener\">German<\/a> or <a href=\"https:\/\/biobank.medunigraz.at\/frontend\/user_upload\/OEs\/oe-forschungsinfrastruktur\/biobank\/pdf\/Informed_Consent_Englisch.pdf\" target=\"_blank\" rel=\"noopener\">English<\/a>), study specific IC<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Access                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Cooperation preferred<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Quality Standards                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>Quality management: ISO 9001:2015 (SOPs)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Contact                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>&nbsp;<\/p>\n<p>Principle Investigator: Assoz. Prof. Dr. Harald Sourij (<a href=\"mailto:biobank-pm@medunigraz.at\">biobank-pm@medunigraz.at<\/a>)<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                    \r\n                        <div class=\"datafield_row\">\r\n                            <div class=\"datafield_title\">\r\n                                Publications and press                            <\/div>\r\n                            <div class=\"datafield_data\">\r\n                                <div class=\"datafield_data_inner\">\r\n                                    <p>&#8222;Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial&#8220; (Advances in Therapy, August 2018, Volume 35, Issue 8) PMID: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6096974\/\" target=\"_blank\" rel=\"noopener\">30046988<\/a>.<\/p>\n                                <\/div>\r\n                            <\/div>\r\n                        <\/div>\r\n\r\n                                        <\/div>\r\n                    \r\n                    <div class=\"links_inner\">\r\n                        <div class=\"btnBox\">\r\n                                                    <a href=\"https:\/\/directory.bbmri-eric.eu\/ERIC\/directory\/#\/catalogue\" target=\"_blank\" class=\"btnBox_inner_link fl_center_vr\">\r\n                                <span class=\"main_btn_icon\"><\/span>\r\n                                <span class=\"main_btn_icon_hover\"><\/span>\r\n                                <span class=\"main_btn_font btnBox_inner\">View this and other cohorts from Biobank Graz in the BBMRI-ERIC Directory<\/span>\r\n                            <\/a>\r\n                                                <\/div>\r\n                    <\/div>\r\n\r\n                                            <div class=\"part_img_cohorts\">\r\n                                                        <img decoding=\"async\" src=\"https:\/\/bbmri.at\/wp-content\/uploads\/2023\/09\/INTERFAST-Cohort-1110x129.jpg\" alt=\"\" class=\"img_datafield\">\r\n                        <\/div>\r\n                    \r\n                    \r\n\r\n\r\n\r\n                <\/div>\r\n                                            <\/div>\r\n\r\n            <div class=\"contentPart-sidebarDummy\"><\/div>\r\n\r\n        <\/div>\r\n    <\/div>\r\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":5668,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"class_list":["post-679","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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