{"id":8490,"date":"2024-02-02T18:35:17","date_gmt":"2024-02-02T17:35:17","guid":{"rendered":"https:\/\/bbmri.at\/?post_type=news-articles&p=8490"},"modified":"2024-07-31T17:26:42","modified_gmt":"2024-07-31T15:26:42","slug":"heterogenitaet-des-transkriptoms-bei-hepatischen-ischaemie-reperfusionsschaeden","status":"publish","type":"news-articles","link":"https:\/\/bbmri.at\/de\/news-articles\/heterogenitaet-des-transkriptoms-bei-hepatischen-ischaemie-reperfusionsschaeden\/","title":{"rendered":"Heterogenit\u00e4t des Transkriptoms bei hepatischen Isch\u00e4mie-Reperfusionssch\u00e4den"},"content":{"rendered":"
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\n Heterogenit\u00e4t des Transkriptoms bei hepatischen Isch\u00e4mie-Reperfusionssch\u00e4den <\/h1>\n \n

\n Rezent publizierte Arbeit von Forscher*innen des BBMRI.at-Partners Med Uni Graz \u00fcber die Auswirkungen der Variabilit\u00e4t zwischen Patient*innen bei isch\u00e4mischen Leberverletzungen auf die pr\u00e4analytische Phase. <\/h3>\n \n
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Isch\u00e4mie-Reperfusionssch\u00e4den k\u00f6nnen zu Ver\u00e4nderungen im Transkriptom von Leberzellen f\u00fchren, was die molekulare Diagnostik und Forschung erschwert. Um mehr \u00fcber diesen Effekt herauszufinden, charakterisierten Forscher*innen der Med Uni Graz die Transkriptome von nicht-b\u00f6sartigen Leberproben, die zu verschiedenen Zeitpunkten der warmen und kalten Isch\u00e4mie gewonnen wurden, und fanden mehrere dysregulierte Gene.<\/p>\n

Die Autor*innen, darunter auch Kurt Zatloukal, der ‚Gr\u00fcnder‘ von BBMRI.at, kamen zu dem Schluss, dass die Heterogenit\u00e4t zwischen den Proben verschiedener Patient*innen auf die unterschiedlichen Grunderkrankungen und die unterschiedlichen Stressreaktionen der Proben in der pr\u00e4analytischen Phase zur\u00fcckzuf\u00fchren ist. Dar\u00fcber hinaus fanden sie 230 Gene, die sehr robust gegen\u00fcber pr\u00e4analytischen Ver\u00e4nderungen sind und als Referenzgene f\u00fcr diagnostische Anwendungen dienen k\u00f6nnten.<\/p>\n

 <\/p>\n

Diese Studie wurde im Rahmen des EU-Projekts SPIDIA (Standardization and Improvement of Generic Pre-analytical Tools and Procedures for In Vitro Diagnostics; http:\/\/www.spidia.eu<\/a>, Grant Agreement Nummer 222916) durchgef\u00fchrt.<\/p>\n <\/div>\n \n

\n \n <\/span>\n <\/span>\n Publikation lesen<\/span>\n <\/a>\n \n \n <\/span>\n <\/span>\n Weitere Ver\u00f6ffentlichungen von BBMRI.at-Partnern<\/span>\n <\/a>\n <\/div>\n <\/div>\n\n\n\n
<\/div>\n <\/div>\n\n <\/div>\n","protected":false},"excerpt":{"rendered":"

Publikation von BBMRI.at-Partner Med Uni Graz<\/p>\n","protected":false},"featured_media":8487,"template":"","meta":{"_acf_changed":false,"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[159],"class_list":["post-8490","news-articles","type-news-articles","status-publish","has-post-thumbnail","hentry","category-publication-de-news-de"],"acf":[],"yoast_head":"\nHeterogenit\u00e4t des Transkriptoms bei hepatischen Isch\u00e4mie-Reperfusionssch\u00e4den - BBMRI.at<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bbmri.at\/de\/news-articles\/heterogenitaet-des-transkriptoms-bei-hepatischen-ischaemie-reperfusionsschaeden\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Heterogenit\u00e4t des Transkriptoms bei hepatischen Isch\u00e4mie-Reperfusionssch\u00e4den - 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