Asset Publisher
Paracelsus 10.000 Cohort
Sample Cohort Profile at BBMRI.at partner PMU / SALK
Paracelsus 10 000 Cohort
This population-based collection of the of samples and data is soon going to reached the mark of 10 000 donors. It comprises samples and data from 5 000 male and 5 000 female probands from Salzburg (Austria).
Purpose of this cohort is to serve the following study aims:
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Collection of valid epidemiological data on the state of health of the Salzburg population
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Clarification of the interaction of genetic disposition and lifestyle factors in the development of degenerative diseases
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Development of well-directed prevention processes for the population of Salzburg
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Strengthening of the research location Salzburg and Austria
CONTACT:
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Prof. Dr. Bernhard Paulweber b.paulweber@salk.at
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Dr. Ludmilla Kedenko PhD l.kedenko@salk.at
COHORT SIZE & DONORS
Representative sample of 10 000 participants (5.000 male, 5.000 female)-by 03/2020- from the city of Salzburg and surrounding townships:
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40-49 years: 2700 participants
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50-59 years: 4300 participants
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60-69 years: 3000 participants
SAMPLE TYPES
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Plasma (EDTA, citrate and
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heparin)
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Serum
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EDTA blood for DNA isolation
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Buffy Coat
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Urine
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Stool samples
ASSOCIATED DATA
1. Basic investigations of all participants:
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Questionnaires on diet, exercise, socio-economic anamnesis, depression, cognitive performance, quality of life, stress and environmental factors
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Anthropometry: height, weight, abdominal girth
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Resting blood pressure, heart rate, resting 12-channel ECG
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Laboratory parameters:
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Lipid profile, Apo-B, Apo-AI, Lp(a), FBS, HbA1c, E-lyte, CR, Urea, LFT, Fe-Status, hsCRP, fibrinogen, BC, TSH, PSA (men), Fasting-Insulin
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Urine: chemistry, albumin/creatinine ratio
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Ultrasound of the carotides
2. Additional investigations for the intensively phenotyped subgroup (50 to 59 years):
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Laboratory parameters: fasting proinsulin, free fatty acids, adiponectin, vitamin D
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Determination of insulin sensitivity and beta cell function by frequently sampled OGTT (with simultaneous determination of insulin, C-peptide and blood glucose at the time points 0 min., 30 min., 60 min., 90 min. and 120 min.)
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Pulmonary function test
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Pulse wave analysis
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Multi-frequency body composition B.I.A.
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Measurement of intima-media thickness and plaque score of carotid arteries
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Measurement of the coronary artery calcium score
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24h blood pressure measurement
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7-day nutrition protocol
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7-day movement monitoring using movement sensors
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Ankle-brachial index
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Hand grip
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6 meter walking test
3. Additional investigations for two participants per day (50 to 59 years):
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Coronary ca-score
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Body fat distribution and bone density (measured with DEXA-scan)
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Ergospirometry
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Ultrasound of the liver