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Paracelsus 10.000 Cohort

Sample Cohort Profile at BBMRI.at partner PMU / SALK

Paracelsus 10 000 Cohort

 

This  population-based collection of the of samples and data is soon going to reached the mark of 10 000 donors. It comprises samples and data from 5 000 male and 5 000 female probands from Salzburg (Austria).

 

Purpose of this cohort is to serve the following study aims:

  • Collection of valid epidemiological data on the state of health of the Salzburg population

  • Clarification of the interaction of genetic disposition and lifestyle factors in the development of degenerative diseases

  • Development of well-directed prevention processes for the population of Salzburg

  • Strengthening of the research location Salzburg and Austria

 

CONTACT:

 

 

COHORT SIZE & DONORS

 

Representative sample of 10 000 participants (5.000 male, 5.000 female)-by 03/2020- from the city of Salzburg and surrounding townships:

  • 40-49 years: 2700 participants

  • 50-59 years: 4300 participants

  • 60-69 years: 3000 participants

 

SAMPLE TYPES

  • Plasma (EDTA, citrate and

  • heparin)                                             

  • Serum

  • EDTA blood for DNA isolation

  • Buffy Coat

  • Urine

  • Stool samples

 

ASSOCIATED DATA

 

1. Basic investigations of all participants:

  • Questionnaires on diet, exercise, socio-economic anamnesis, depression, cognitive performance, quality of life, stress and environmental factors

  • Anthropometry: height, weight, abdominal girth

  • Resting blood pressure, heart rate, resting 12-channel ECG

  • Laboratory parameters:

  • Lipid profile, Apo-B, Apo-AI, Lp(a), FBS, HbA1c, E-lyte, CR, Urea, LFT, Fe-Status, hsCRP, fibrinogen, BC, TSH, PSA (men), Fasting-Insulin

  • Urine: chemistry, albumin/creatinine ratio

  • Ultrasound of the carotides

 

2. Additional investigations for the intensively phenotyped subgroup (50 to 59 years):

  • Laboratory parameters: fasting proinsulin, free fatty acids, adiponectin, vitamin D

  • Determination of insulin sensitivity and beta cell function by frequently sampled OGTT (with simultaneous determination of insulin, C-peptide and blood glucose at the time points 0 min., 30 min., 60 min., 90 min. and 120 min.)

  • Pulmonary function test

  • Pulse wave analysis

  • Multi-frequency body composition B.I.A.

  • Measurement of intima-media thickness and plaque score of carotid arteries

  • Measurement of the coronary artery calcium score

  • 24h blood pressure measurement

  • 7-day nutrition protocol

  • 7-day movement monitoring using movement sensors

  • Ankle-brachial index

  • Hand grip

  • 6 meter walking test


3. Additional investigations for two participants per day (50 to 59 years):

  • Coronary ca-score

  • Body fat distribution and bone density (measured with DEXA-scan)

  • Ergospirometry

  • Ultrasound of the liver

 

View details at SALK website >>

View details (pdf) >>